• metastatic/advanced - colorectal cancer (mCRC)
• mCRC - 1st line (L1) 1
• mCRC - 2nd line (L2) 3
• endometrial cancer 1
• esophageal cancer (EC)

 

• immune chekpoint inhibitors
• anti-PD-(L)1
• atezolizumab based treatment
• atezolizumab alone
• atezolizumab plus cometinib
• Immune checkpoint association
• durvalumab plus tremelimumab

• versus all
• vs non active control
• vs BSC
• vs placebo
• vs VEGF(R) inhibitor
• vs regorafenib

• study list
• mapping
• overview
• meta-analysis
• forest plot
• NMA
• excluded

Top evidence (RCT only, high risk of bias excluded) Best available evidence (possibly low or very low) All RCTs All studies (RCT+OBS)

Pathology:  mCRC - 2nd line (L2);