• metastatic-recurrent HNSCC (mHNSCC)
• mHNSCC - (neo)adjuvant (NA)
• mHNSCC - 1st line (L1)
• mHNSCC - L1 - all population 2
• mHNSCC - L1 - PDL1 positive 4
• mHNSCC - 2nd line (L2)
• mHNSCC - L2 - all population 4
• mHNSCC - L2 - PDL1 negative 2
• mHNSCC - L2 - PDL1 positive 1
• hepatocell cancer (HCC) 1

 

• immune chekpoint inhibitors
• anti-PD-(L)1
• pembrolizumab based treatment
• pembrolizumab alone
• pembrolizumab plus 5FU plus platin

• versus all
• vs HER inhibitor
• vs EGFR inhibitor
• vs cetuximab based chemotherapy
• vs cetuximab plus platin plus 5FU

• study list
• mapping
• overview
• meta-analysis
• forest plot
• NMA
• excluded

Top evidence (RCT only, high risk of bias excluded) Best available evidence (possibly low or very low) All RCTs All studies (RCT+OBS)

Pathology:  mHNSCC - L1 - PDL1 positive;