buparlisib plus fulvestranttitlealpelisib plus letrozoletitlealpelisib plus fulvestranttitletaselisib plus letrozoletitlebuparlisib plus letrozoletitleletrozoletitlefulvestranttitleLORELEI, 2019 NCT02273973 es-BC - HR-positive - 1st line (L1) 166/168BELLE-2 (patients with known PI3K status), 2017 NCT01610284 la/mBC - HR positive 427/424NEO-ORB (wild type cohort), 2019 NCT01923168 la/mBC - HR positive - (neo)adjuvant (NA) 131/126NEO-ORB (mutant cohort), 2019 NCT01923168 la/mBC - HR positive - (neo)adjuvant (NA) -9/126NEO-ORB (buparlisib vs placebo), 2019 NCT01923168 la/mBC - HR positive - (neo)adjuvant (NA) -9/-9BELLE-2 (full population), 2017 NCT01610284 la/mBC - HR positive - L2 - all population 576/571BELLE-2 (PI3K pathway activated), 2017 NCT01610284 la/mBC - HR positive - L2 - PIK3CA mutant 188/184SOLAR-1 (patients with PIK3CA mutant status), 2019 NCT02437318 la/mBC - HR-positive - 2nd line (L2) 169/172SOLAR-1 (patients without PIK3CA mutant status), 2019 NCT02437318 la/mBC - HR-positive - 2nd line (L2) 115/116BELLE-3, 2018 NCT01633060 la/mBC - HR-positive - 2nd line (L2) 289/143

Pathology:  es-BC - HR-positive - 1st line (L1);   la/mBC - HR positive;   la/mBC - HR positive - (neo)adjuvant (NA);   la/mBC - HR positive - L2 - all population;   la/mBC - HR positive - L2 - PIK3CA mutant;   la/mBC - HR-positive - 2nd line (L2); 

es-BC - HR-positive - 1st line (L1)la/mBC - HR positivela/mBC - HR positive - (neo)adjuvant (NA)la/mBC - HR positive - L2 - all populationla/mBC - HR positive - L2 - PIK3CA mutantla/mBC - HR-positive - 2nd line (L2)
LORELEI, 2019BELLE-2 (patients with known PI3K status), 2017NEO-ORB (wild type cohort), 2019NEO-ORB (mutant cohort), 2019NEO-ORB (buparlisib vs placebo), 2019BELLE-2 (full population), 2017BELLE-2 (PI3K pathway activated), 2017SOLAR-1 (patients with PIK3CA mutant status), 2019SOLAR-1 (patients without PIK3CA mutant status), 2019BELLE-3, 2018
buparlisib plus fulvestrant4T1T1T1T1
alpelisib plus letrozole2T1T1
alpelisib plus fulvestrant2T1T1
taselisib plus letrozole1T1
buparlisib plus letrozole1T1
letrozole0T0T0T0T0
fulvestrant0T0T0T0T0T0T0