• metastatic-recurrent HNSCC (mHNSCC)
• mHNSCC - (neo)adjuvant (NA)
• mHNSCC - 1st line (L1)
• mHNSCC - L1 - all population 2
• mHNSCC - L1 - PDL1 positive 4
• mHNSCC - 2nd line (L2)
• mHNSCC - L2 - all population 4
• mHNSCC - L2 - PDL1 negative 2
• mHNSCC - L2 - PDL1 positive 1
• hepatocell cancer (HCC) 1

 

• immune chekpoint inhibitors
• anti-PD-(L)1
• atezolizumab based treatment
• atezolizumab plus bevacizumab
• atezolizumab plus cabozantinib
• camrelizumab based treatment
• durvalumab based treatment
• durvalumab plus bevacizumab
• nivolumab based treatment
• nivolumab alone
• pembrolizumab based treatment
• pembrolizumab alone
• pembrolizumab plus lenvatinib
• sintilimab based treatment
• sintilimab
• Tislelizumab
• Immune checkpoint association
• durvalumab plus tremelimumab
• nivolumab plus ipilimumab
• nivolumab plus ipilimumab plus SoC
• VEGF(R) inhibitor
• bevacizumab based treatment
• bevacizumab

• versus all
• vs chemotherapy
• vs Standard of Care (SoC)
• vs immune chekpoint inhibitors
• vs anti-PD-(L)1
• vs atezolizumab based treatment
• vs atezolizumab plus bevacizumab
• vs nivolumab based treatment
• vs nivolumab alone
• vs non active control
• vs no additional treatment
• vs no control (uncontrolled study)
• vs placebo
• vs VEGF(R) inhibitor
• vs lenvatinib
• vs sorafenib

• study list
• mapping
• overview
• meta-analysis
• forest plot
• NMA
• excluded

Top evidence (RCT only, high risk of bias excluded) Best available evidence (possibly low or very low) All RCTs All studies (RCT+OBS)

Comparator:  vs sorafenib; 
Risk of bias:  low;   some concerns;   high;  NA;