trastuzumab based treatment
trastuzumab plus epirubicin and cyclophosphamide followed by docetaxel
es-BC - HER2 positive - (neo)adjuvant (NA) 4   
Comparator:  vs lapatinib plus epirubicin and cyclophosphamide followed by docetaxel; 
Risk of bias:  low;   some concerns;   high;  NA;