metaEvidence

graph Evidence gap map comparisons

	avelumab based treatment	durvalumab based treatment	nivolumab based treatment	pembrolizumab based treatment		Immune checkpoint association
	avelumab alone	durvalumab alone	nivolumab alone	pembrolizumab alone	pembrolizumab plus 5FU plus platin	durvalumab plus tremelimumab

Comparator: vs placebo; vs cetuximab plus platin plus 5FU; vs Standard of Care (SoC); vs durvalumab alone; vs tremelimumab;
Risk of bias: low; some concerns; high; NA;