graph Evidence gap map comparisons
trastuzumab based treatment
docetaxel plus carboplatin with trastuzumab followed by trastuzumab doxorubicin plus cyclophosphamide followed by docetaxel plus trastuzumab trastuzumab plus endocrine therapy trastuzumab plus epirubicin and cyclophosphamide followed by docetaxel
Comparator:  vs doxorubicin plus cyclophosphamide followed by docetaxel;   vs docetaxel plus carboplatin with trastuzumab followed by trastuzumab;   vs lapatinib plus epirubicin and cyclophosphamide followed by docetaxel;   vs trastuzumab plus chemotherapy; 
Risk of bias:  low;   some concerns;   high;  NA;