graph Evidence gap map comparisons
pembrolizumab based treatment
pembrolizumab alone pembrolizumab and pemetrexed plus platin pembrolizumab plus SoC
mNSCLC - L1 - all population 5
mNSCLC - L1 - EGFR mutant
mNSCLC - L1 - PDL1 negative 1
mNSCLC - L1 - PDL1 positive 14    
mNSCLC - L1 - TMB>10Mb 1
non squamous cell - mNSCLC - L1
non squamous - mNSCLC - L1 - all population 3
non squamous - mNSCLC - L1 - PDL1 positive
non squamous - mNSCLC - L1 - Wild Type (WT) 6     
squamous cell - mNSCLC - L1
squamous - mNSCLC - L1 - all population 4   
squamous - mNSCLC - L1 - PDL1 positive
squamous - mNSCLC - L1 - Wild Type (WT)
Comparator:  vs Standard of Care (SoC);   vs pemetrexed plus platin;   vs placebo plus SoC; 
Risk of bias:  low;   some concerns;   high;  NA;