ipilimumab based treatmentatezolizumab based treatmentavelumab based treatmentanti-PD-(L)1durvalumab based treatmentdurvalumab alonenivolumab based treatmentpembrolizumab based treatmentpembrolizumab alonepembrolizumab based treatmentsintilimab based treatmentanti-PD-(L)1Immune checkpoint associationnivolumab plus ipilimumabImmune checkpoint association
ipilimumab plus SoC atezolizumab alone atezolizumab plus bevacizumab plus carboplatin plus paclitaxel atezolizumab plus carboplatin plus nab-paclitaxel atezolizumab plus carboplatin plus paclitaxel atezolizumab plus pemetrexed and platin avelumab alone cemiplimab durvalumab alone durvalumab plus osimertinib nivolumab alone nivolumab plus SoC pembrolizumab alone pembrolizumab (10mg/kg) pembrolizumab (2mg/kg) pembrolizumab and pemetrexed plus platin pembrolizumab plus SoC sintillimab plus SoC Tislelizumab durvalumab plus tremelimumab nivolumab plus ipilimumab nivolumab plus ipilimumab plus SoC pembrolizumab plus ipilimumab
Comparator:  vs placebo;   vs placebo plus SoC;   vs Standard of Care (SoC);   vs pemetrexed plus platin;   vs pembrolizumab plus placebo;   vs docetaxel;   vs osimertinib;   vs bevacizumab plus carboplatin and paclitaxel;   vs atezolizumab plus carboplatin plus nab-paclitaxel;   vs carboplatin plus nab-paclitaxel;   vs nab-paclitaxel; 
Risk of bias:  low;   some concerns;   high;  NA;