pembrolizumab alone (n=314) vs. Standard of Care (SoC) (n=314)
randomized controlled trial
Pembrolizumab
pembrolizumab 200 mg Q3W for up to 2 years
chemotherapy ICC (paclitaxel, docetaxel, or irinotecan)
investigator’s choice chemo of paclitaxel, docetaxel, or irinotecan.paclitaxel 80-100 mg/m on days 1, 8, and 15 Q4W, docetaxel 75 mg/m Q3W, or irinotecan 180 mg/m Q2W.