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metformin (n=22) vs. placebo (n=18)
randomized controlled trial
metformin plus chemotherapy metformin: 850mg PO / with chemotherapy consisting of anthracycline, platinum, taxane, capecitabine orvinorelbine pre-specified by their treating physician
placebo plus chemotherapy
la/mBC - HR-positive - 2nd line (L2)
double blind
P2 / 1-side at 20%
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