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Vaxzevria (AstraZeneca Oxford - ChAdOx1 nCoV-19) in COVID-19 prophylaxis (excluding children) - Summary of results

OutcomeTE95% CInkI2ROBPub. bias symptomatic Covid-19detailed resultsAstraZeneca phase 3 US (D8110C00001), 2021 0.24 [0.18; 0.32] 0.24[0.18; 0.32]AstraZeneca phase 3 US (D8110C00001), 202110%NAnot evaluable adverse eventsdetailed resultsAsano, 2022 1.44 [0.71; 2.93] AstraZeneca phase 3 US (D8110C00001), 2021 1.62 [1.54; 1.71] 1.62[1.54; 1.70]Asano, 2022, AstraZeneca phase 3 US (D8110C00001), 202120%32,635NAnot evaluable ATE (Myocardial infarction or ischemic stroke)detailed resultsAstraZeneca phase 3 US (D8110C00001), 2021 0.12 [0.01; 2.77] 0.12[0.01; 2.77]AstraZeneca phase 3 US (D8110C00001), 202110%32,379NAnot evaluable Guillain-Barré syndrome detailed resultsAstraZeneca phase 3 US (D8110C00001), 2021 1.00 [0.03; 29.81] 1.00[0.03; 29.81]AstraZeneca phase 3 US (D8110C00001), 202110%32,379NAnot evaluable intracranial hemorrhage detailed resultsAsano, 2022 0.33 [0.01; 16.88] AstraZeneca phase 3 US (D8110C00001), 2021 0.50 [0.01; 25.21] 0.41[0.03; 6.54]Asano, 2022, AstraZeneca phase 3 US (D8110C00001), 202120%32,635NAnot evaluable ischemic strokedetailed resultsAsano, 2022 0.33 [0.01; 16.88] AstraZeneca phase 3 US (D8110C00001), 2021 0.13 [0.01; 2.77] 0.18[0.02; 2.07]Asano, 2022, AstraZeneca phase 3 US (D8110C00001), 202120%32,635NAnot evaluable Myocardial infarction detailed resultsAsano, 2022 0.33 [0.01; 16.88] AstraZeneca phase 3 US (D8110C00001), 2021 0.25 [0.01; 7.46] 0.28[0.02; 3.68]Asano, 2022, AstraZeneca phase 3 US (D8110C00001), 202120%32,635NAnot evaluable pulmonary embolismdetailed resultsAsano, 2022 0.33 [0.01; 16.88] AstraZeneca phase 3 US (D8110C00001), 2021 0.50 [0.01; 25.21] 0.41[0.03; 6.54]Asano, 2022, AstraZeneca phase 3 US (D8110C00001), 202120%32,635NAnot evaluable serious adverse events (SAE), anydetailed resultsAsano, 2022 0.16 [0.01; 4.96] AstraZeneca phase 3 US (D8110C00001), 2021 0.95 [0.68; 1.33] 0.93[0.61; 1.41]Asano, 2022, AstraZeneca phase 3 US (D8110C00001), 202121%32,635NAnot evaluable Bell's palsydetailed resultsAstraZeneca phase 3 US (D8110C00001), 2021 1.00 [0.03; 29.81] 1.00[0.03; 29.81]AstraZeneca phase 3 US (D8110C00001), 202110%32,379NAnot evaluable0.05.01.0relative treatment effectwww.metaEvidence.org2024-05-11 19:13 +02:00

TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers); k: number of studies; n: total number of patients; ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1; studied treatment is better when TE < 1;

pathologies: 89 - treatments: 759 - roots T: 290