standard of care in COVID 19 hospitalized - Summary of results Outcome TE 95% CI n k I2 ROB Pub. bias death D28detailed results COALITION II Covid-19 Brazil (Furtado), 2020 (REV) 0.93 [0.68; 1.26]
RECOVERY (AZI, Horby), 2020 (REV) 1.03 [0.93; 1.14]
1.02 [0.92 ; 1.13 ] COALITION II Covid-19 Brazil (Furtado), 2020 (REV), RECOVERY (AZI, Horby), 2020 (REV) 2 0% 8,161 moderate not evaluable deathsdetailed results COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020 (REV) 2.33 [0.70; 7.77]
COALITION II Covid-19 Brazil (Furtado), 2020 (REV) 0.93 [0.68; 1.26]
RECOVERY (AZI, Horby), 2020 (REV) 1.03 [0.93; 1.14]
Sekhavati, 2020 (REV) 2.06 [0.07; 62.55]
1.03 [0.93 ; 1.13 ] COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020 (REV), COALITION II Covid-19 Brazil (Furtado), 2020 (REV), RECOVERY (AZI, Horby), 2020 (REV), Sekhavati, 2020 (REV) 4 0% 8,603 moderate not evaluable deaths (time to event analysis only)detailed results COALITION II Covid-19 Brazil (Furtado), 2020 (REV) 0.93 [0.68; 1.26]
RECOVERY (AZI, Horby), 2020 (REV) 1.03 [0.93; 1.14]
1.02 [0.92 ; 1.13 ] COALITION II Covid-19 Brazil (Furtado), 2020 (REV), RECOVERY (AZI, Horby), 2020 (REV) 2 0% 8,161 moderate not evaluable clinical improvementdetailed results COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020 (REV) 1.22 [0.70; 2.13]
COALITION II Covid-19 Brazil (Furtado), 2020 (REV) 1.35 [0.94; 1.95]
1.31 [0.97 ; 1.78 ] COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020 (REV), COALITION II Covid-19 Brazil (Furtado), 2020 (REV) 2 0% 728 moderate not evaluable clinical improvement (14-day)detailed results COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020 (REV) 1.22 [0.70; 2.13]
COALITION II Covid-19 Brazil (Furtado), 2020 (REV) 1.35 [0.94; 1.95]
1.31 [0.97 ; 1.78 ] COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020 (REV), COALITION II Covid-19 Brazil (Furtado), 2020 (REV) 2 0% 728 moderate not evaluable clinical improvement (28-day)detailed results COALITION II Covid-19 Brazil (Furtado), 2020 (REV) 1.43 [0.96; 2.13]
1.43 [0.96 ; 2.13 ] COALITION II Covid-19 Brazil (Furtado), 2020 (REV) 1 0% 397 NA not evaluable clinical improvement (7-day)detailed results COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020 (REV) 1.12 [0.74; 1.71]
COALITION II Covid-19 Brazil (Furtado), 2020 (REV) 1.06 [0.71; 1.58]
1.09 [0.82 ; 1.46 ] COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020 (REV), COALITION II Covid-19 Brazil (Furtado), 2020 (REV) 2 0% 728 moderate not evaluable death or ventilationdetailed results RECOVERY (AZI, Horby), 2020 (REV) 1.05 [0.97; 1.15]
1.05 [0.97 ; 1.15 ] RECOVERY (AZI, Horby), 2020 (REV) 1 0% 7,764 NA not evaluable hospital dischargedetailed results RECOVERY (AZI, Horby), 2020 (REV) 0.96 [0.91; 1.02]
0.96 [0.91 ; 1.02 ] RECOVERY (AZI, Horby), 2020 (REV) 1 0% 7,764 NA not evaluable mechanical ventilationdetailed results COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020 (REV) 0.65 [0.30; 1.42]
RECOVERY (AZI, Horby), 2020 (REV) 1.09 [0.93; 1.26]
Sekhavati, 2020 (REV) 6.40 [0.31; 130.93]
1.00 [0.62 ; 1.60 ] COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020 (REV), RECOVERY (AZI, Horby), 2020 (REV), Sekhavati, 2020 (REV) 3 32% 8,206 moderate not evaluable radiologic improvement (14-day)detailed results Rashad A (AZI vs SoC), 2021 (REV) 0.61 [0.35; 1.07]
0.61 [0.35 ; 1.07 ] Rashad A (AZI vs SoC), 2021 (REV) 1 0% 206 NA not evaluable ICU admissiondetailed results Sekhavati, 2020 (REV) 3.94 [0.78; 19.87]
3.94 [0.78 ; 19.87 ] Sekhavati, 2020 (REV) 1 0% 111 NA not evaluable related SAE (TRSAE)detailed results COALITION II Covid-19 Brazil (Furtado), 2020 (REV) 0.80 [0.32; 2.01]
0.80 [0.32 ; 2.01 ] COALITION II Covid-19 Brazil (Furtado), 2020 (REV) 1 0% 439 NA not evaluable serious adverse eventsdetailed results COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020 (REV) 0.98 [0.20; 4.92]
COALITION II Covid-19 Brazil (Furtado), 2020 (REV) 0.83 [0.57; 1.22]
0.84 [0.58 ; 1.22 ] COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020 (REV), COALITION II Covid-19 Brazil (Furtado), 2020 (REV) 2 0% 877 moderate not evaluable adverse eventsdetailed results COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020 (REV) 0.83 [0.56; 1.23]
0.83 [0.56 ; 1.23 ] COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020 (REV) 1 0% 438 NA not evaluable arrhythmiadetailed results RECOVERY (AZI, Horby), 2020 (REV) 1.11 [0.87; 1.41]
Sekhavati, 2020 (REV) 1.02 [0.02; 52.25]
1.11 [0.87 ; 1.41 ] RECOVERY (AZI, Horby), 2020 (REV), Sekhavati, 2020 (REV) 2 0% 7,874 moderate not evaluable long QTdetailed results COALITION II Covid-19 Brazil (Furtado), 2020 (REV) 1.11 [0.70; 1.77]
1.11 [0.70 ; 1.77 ] COALITION II Covid-19 Brazil (Furtado), 2020 (REV) 1 0% 439 NA not evaluable renal impairmentdetailed results COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020 (REV) 0.74 [0.26; 2.12]
COALITION II Covid-19 Brazil (Furtado), 2020 (REV) 0.69 [0.47; 1.01]
0.70 [0.49 ; 1.00 ] COALITION I Covid-19 Brazil (AZI, Cavalcanti), 2020 (REV), COALITION II Covid-19 Brazil (Furtado), 2020 (REV) 2 0% 770 moderate not evaluable 0.2 10.0 1.0 relative treatment effect www.metaEvidence.org 2024-05-04 00:14 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
pathologies: 95,94,90,91
- treatments: 651
- roots T: 651
