Early convalescent plasma. - versus Deferred Convalescent plasma - for COVID 19 hospitalized pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death D28 4.22 [0.33, 53.77]< 10%1 study (1/-)13.6 %NAnot evaluable crucial-
deaths 3.26 [0.62, 17.12]< 10%1 study (1/-)8.2 %NAnot evaluable crucial-
deaths (time to event analysis only) 3.26 [0.62, 17.12]< 10%1 study (1/-)8.2 %NAnot evaluable crucial-
clinical deterioration 1.46 [0.44, 4.81]< 10%1 study (1/-)26.7 %NAnot evaluable important-
clinical improvement 0.91 [0.52, 1.60]> 10%1 study (1/-)37.2 %NAnot evaluable important-
clinical improvement (time to event analysis only) 0.91 [0.52, 1.60]> 10%1 study (1/-)37.2 %NAnot evaluable important-
death or ventilation 0.67 [0.14, 3.26]< 10%1 study (1/-)69.0 %NAnot evaluable important-
mechanical ventilation 2.98 [0.41, 21.61]< 10%1 study (1/-)14.1 %NAnot evaluable important-
viral clearance 2.66 [0.69, 10.20]> 10%1 study (1/-)92.2 %NAnot evaluable important-
viral clearance by day 7 2.66 [0.69, 10.20]> 10%1 study (1/-)92.2 %NAnot evaluable important-

safety endpoints 00

serious adverse events 4.54 [0.20, 105.23]< 10%1 study (1/-)17.6 %NAnot evaluable important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.