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CanSino (Convidecia) - versus control - for COVID-19 prophylaxis (excluding children) pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

safety endpoints 00

ischemic stroke 0.33 [0.01, 16.67]< 10%1 study (1/-)70.7 %NAnot evaluable non important-
Myocardial infarction 0.33 [0.01, 16.67]< 10%1 study (1/-)70.7 %NAnot evaluable non important-
pulmonary embolism 0.33 [0.01, 16.67]< 10%1 study (1/-)70.7 %NAnot evaluable non important-

reactogenicity (vaccines) endpoints 00

systemic adverse reaction, any, dose 1 20.24 [10.60, 38.63]< 10%1 study (1/-)0.0 %NAnot evaluable non important-
systemic adverse reaction, any, dose 2 4.39 [2.05, 9.41]< 10%1 study (1/-)0.0 %NAnot evaluable non important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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