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Immunostimulants drugs - versus placebo - for COVID-19 severe or critically pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death D28 0.83 [0.43, 1.59]< 141%3 studies (3/-)71.3 %lownot evaluable highcrucial-
death or transfer to ICU 0.65 [0.35, 1.22]< 10%1 study (1/-)90.9 %NAnot evaluable crucial-
deaths 0.75 [0.46, 1.21]< 122%4 studies (4/-)88.0 %lownot evaluable highcrucial-
deaths (time to event analysis only) 1.08 [0.59, 1.97]< 10%2 studies (2/-)40.0 %lownot evaluable highcrucial-
clinical improvement 1.03 [0.88, 1.19]> 113%4 studies (4/-)63.8 %some concernnot evaluable moderateimportant-
clinical improvement (14-day) 1.01 [0.79, 1.29]> 10%1 study (1/-)53.2 %NAnot evaluable important-
clinical improvement (28-day) 1.38 [0.73, 2.61]> 10%1 study (1/-)83.9 %NAnot evaluable important-
clinical improvement (time to event analysis only) 1.02 [0.91, 1.13]> 10%3 studies (3/-)60.6 %some concernnot evaluable moderateimportant-
mechanical ventilation 1.03 [0.53, 2.00]< 10%2 studies (2/-)46.4 %lownot evaluable highimportant-
ICU admission 0.67 [0.35, 1.28]< 10%1 study (1/-)88.9 %NAnot evaluable non important-

safety endpoints 00

serious adverse events 0.95 [0.44, 2.05]< 170%2 studies (2/-)55.3 %lownot evaluable highimportant-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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