antiviral and associated therapy - versus potential COVID-19 treatments - for COVID-19 prophylaxis (excluding children) pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

deaths 0.73 [0.28, 1.87]< 10%6 studies (6/-)74.5 %some concernnot evaluable moderatecrucial-
conversion to SARS-CoV- 2–positive status via NP swab 2.27 [1.09, 4.76]< 10%1 study (1/-)1.5 %NAnot evaluable important-
hospitalization 0.61 [0.10, 3.85]< 10%3 studies (3/-)69.9 %lownot evaluable highimportant-
new illness compatible with Covid-19 0.06 [0.03, 0.14]< 173%4 studies (4/-)100.0 %highnot evaluable lowimportant-
symptomatic Covid-19 0.94 [0.75, 1.17]< 110%7 studies (7/-)71.7 %some concernnot evaluable moderateimportant-
asymptomatic COVID case 0.96 [0.49, 1.90]< 10%1 study (1/-)54.4 %NAnot evaluable non important-
ICU admission 1.00 [0.02, 52.45]< 10%1 study (1/-)50.0 %NAnot evaluable non important-
infection (PCR positive symptomatic or not) 0.83 [0.58, 1.17]< 170%11 studies (11/-)86.1 %some concernlow moderatenon important-

safety endpoints 00

serious adverse events 0.90 [0.47, 1.72]< 10%4 studies (4/-)62.9 %some concernnot evaluable moderateimportant-
adverse events 3.62 [1.25, 10.48]< 197%6 studies (6/-)0.9 %some concernnot evaluable moderatenon important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.