Table Graph
   

corticosteroids - versus standard of care - for COVID 19 hospitalized pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death D28 0.98 [0.67, 1.45]< 10%4 studies (4/-)53.1 %highnot evaluable lowcrucial-
deaths 0.83 [0.67, 1.02]< 140%9 studies (9/-)96.4 %some concernnot evaluable moderatecrucial-
deaths (time to event analysis only) 0.67 [0.35, 1.31]< 181%3 studies (3/-)87.8 %highnot evaluable lowcrucial-
clinical deterioration 0.66 [0.43, 1.02]< 10%1 study (1/-)96.9 %NAnot evaluable important-
clinical improvement 1.81 [0.89, 3.70]> 172%3 studies (3/-)94.8 %highnot evaluable lowimportant-
clinical improvement (14-day) 1.16 [0.84, 1.60]> 10%2 studies (2/-)81.0 %highnot evaluable lowimportant-
death or ventilation 1.31 [0.70, 2.46]< 170%3 studies (3/-)19.6 %highnot evaluable lowimportant-
hospital discharge 1.10 [1.03, 1.17]> 10%1 study (1/-)99.8 %NAnot evaluable important-
mechanical ventilation 0.79 [0.63, 0.99]< 11%2 studies (2/-)97.8 %some concernnot evaluable moderateimportant-
radiologic improvement (14-day) 4.89 [1.15, 20.79]> 10%1 study (1/-)98.4 %NAnot evaluable important-
ICU admission 0.85 [0.27, 2.67]< 10%1 study (1/-)60.9 %NAnot evaluable non important-

safety endpoints 00

serious adverse events 1.06 [0.41, 2.77]< 117%4 studies (4/-)44.9 %highnot evaluable lowimportant-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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