|Outcome||Relative effect 95%CI||LoD||Trt. better when||I2||k (RCT/OBS)||Bayesian probability||Overall ROB||Publication bias||Degree of certainty||Endpoint importance||Published MA|
|clinical improvement||1.19 [0.81, 1.75]||> 1||0%||1 study (1 / -)||81.0 %||some concern||not evaluable||moderate||crucial||-|
|clinical improvement (28-day)||1.19 [0.81, 1.75]||> 1||0%||1 study (1 / -)||81.0 %||some concern||not evaluable||moderate||crucial||-|
|deaths||1.02 [0.62, 1.68]||< 1||0%||1 study (1 / -)||47.2 %||some concern||not evaluable||moderate||crucial||-|
|deaths (time to event analysis only)||no RCT reported results for this endpoint, but 2 observational studies are available. Clear RCT filter to include observational studies|
LoD: level of demonstration ( demonstrated, suggested, inconclusive, safety concerns);
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.