interferon - versus control - for COVID-19 severe or critically pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death D28 1.74 [0.51, 5.93]< 10%1 study (1/-)18.9 %NAnot evaluable crucial-
deaths 0.58 [0.25, 1.37]< 134%4 studies (4/-)89.3 %some concernnot evaluable moderatecrucial-
deaths (time to event analysis only) 1.74 [0.51, 5.93]< 10%1 study (1/-)18.9 %NAnot evaluable crucial-
clinical improvement 1.40 [0.61, 3.23]> 179%2 studies (2/-)78.6 %some concernnot evaluable moderateimportant-
clinical improvement (14-day) 1.01 [0.79, 1.29]> 10%1 study (1/-)53.2 %NAnot evaluable important-
clinical improvement (time to event analysis only) 1.66 [0.90, 3.06]> 174%4 studies (4/-)94.9 %some concernnot evaluable moderateimportant-
hospital discharge 3.44 [0.64, 18.49]> 10%1 study (1/-)92.4 %NAnot evaluable important-
mechanical ventilation 0.75 [0.34, 1.69]< 10%3 studies (3/-)75.5 %some concernnot evaluable moderateimportant-
ICU admission 0.49 [0.24, 1.00]< 10%3 studies (3/-)97.4 %some concernnot evaluable moderatenon important-

safety endpoints 00

superinfection 0.18 [0.02, 1.59]< 10%1 study (1/-)93.8 %NAnot evaluable important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.