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Janssen AD26 vaccine (JNJ-78436735) - versus mRNA vaccine - for COVID-19 prophylaxis (excluding children) pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

hospitalization 6.70 [4.60, 9.76]< 10%1 study (-/1)0.0 %NAnot evaluable important-

safety endpoints 00

intracranial hemorrhage 2.05 [0.04, 103.83]< 10%1 study (-/1)36.3 %NAnot evaluable non important-
ischemic stroke 2.05 [0.04, 103.83]< 10%1 study (-/1)36.3 %NAnot evaluable non important-
Myocardial infarction 2.04 [0.16, 26.71]< 10%2 studies (1/1)29.5 %NAnot evaluable non important-
pulmonary embolism 2.05 [0.04, 103.83]< 10%1 study (-/1)36.3 %NAnot evaluable non important-
serious adverse events (SAE), any 1.53 [0.25, 9.36]< 10%1 study (1/-)32.3 %NAnot evaluable non important-
venous thromboembolism 2.03 [0.07, 61.21]< 10%1 study (1/-)34.4 %NAnot evaluable non important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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