Table Graph
   

corticosteroids - versus standard of care - for COVID-19 severe or critically pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death D28 1.19 [0.38, 3.72]< 10%1 study (3/-)38.6 %NAnot evaluable crucial-
deaths 0.99 [0.75, 1.31]< 10%4 studies (7/-)53.1 %some concernnot evaluable moderatecrucial-
deaths (time to event analysis only) 0.67 [0.35, 1.31]< 181%3 studies (3/-)87.8 %highnot evaluable lowcrucial-
clinical deterioration 0.66 [0.43, 1.02]< 10%1 study (1/-)96.9 %NAnot evaluable important-
clinical improvement 1.81 [0.89, 3.70]> 172%3 studies (3/-)94.8 %highnot evaluable lowimportant-
clinical improvement (14-day) 1.16 [0.84, 1.60]> 10%2 studies (2/-)81.0 %highnot evaluable lowimportant-
death or ventilation 1.82 [0.84, 3.95]< 142%2 studies (2/-)6.6 %highnot evaluable lowimportant-
mechanical ventilation 1.38 [0.45, 4.20]< 10%1 study (1/-)28.6 %NAnot evaluable important-
radiologic improvement (14-day) 4.89 [1.15, 20.79]> 10%1 study (1/-)98.4 %NAnot evaluable important-

safety endpoints 00

serious adverse events 0.53 [0.17, 1.62]< 10%1 study (4/-)86.8 %NAnot evaluable important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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