azithromycin - versus control - for COVID-19 severe or critically pdf   xlsx method abbreviations

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

death D28 1.08 [0.79, 1.47]< 10%1 study (1/-)31.4 %NAnot evaluable crucial-
deaths 1.08 [0.79, 1.47]< 10%1 study (1/-)31.4 %NAnot evaluable crucial-
deaths (time to event analysis only) 1.08 [0.79, 1.47]< 10%1 study (1/-)31.4 %NAnot evaluable crucial-
clinical improvement 0.74 [0.51, 1.07]> 10%1 study (1/-)5.3 %NAnot evaluable important-
clinical improvement (14-day) 0.74 [0.51, 1.07]> 10%1 study (1/-)5.3 %NAnot evaluable important-
clinical improvement (28-day) 0.70 [0.47, 1.04]> 10%1 study (1/-)3.9 %NAnot evaluable important-
clinical improvement (7-day) 0.94 [0.63, 1.40]> 10%1 study (1/-)38.0 %NAnot evaluable important-

safety endpoints 00

related SAE (TRSAE) 1.24 [0.50, 3.11]< 10%1 study (1/-)32.0 %NAnot evaluable important-
serious adverse events 1.20 [0.82, 1.77]< 10%1 study (1/-)17.3 %NAnot evaluable important-
long QT 0.90 [0.56, 1.43]< 10%1 study (1/-)67.1 %NAnot evaluable non important-
renal impairment 1.44 [0.99, 2.11]< 10%1 study (1/-)3.0 %NAnot evaluable non important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.