All patients
Age < 65y (younger) Age > 65y Age > 75y (older) ECOG 0 ECOG 1 Gender, female Gender, male LDH > ULN LDH ≤ULN metastasis (brain) NO metastasis (brain) YES metastasis (liver ) PD-L1 < 5% PD-L1 > 5% PDL1 (TC0 and IC0 : <1% of TC and IC) PDL1 (TC1/2/3 or IC1/2/3 : ≥1% of TC or IC) Prior anti-CTLA4 benefit NO Prior anti-CTLA4 benefit YES stage III (locally advanced) stage IV (metastatic) stage M0 stage M0/M1A/M1B stage M1A stage M1B stage M1C
Top evidence (RCT only, high risk of bias excluded)
Best available evidence (possibly low or very low)
All RCTs
All studies (RCT+OBS)
studies
mML - L1 - BRAF wild, immune chekpoint inhibitors vs. ipilimumab based treatment, meta-analysis of study results Outcome TE 95% CI n k I2 ROB Pub. bias progression or deaths (PFS)detailed results CheckMate 069 (BRAF wild type), 2015 0.40 [0.23; 0.69]
0.40 [0.23 ; 0.69 ] CheckMate 069 (BRAF wild type), 2015 1 0% 109 NA not evaluable objective responses (ORR)detailed results CheckMate 069 (BRAF wild type), 2015 12.96 [3.47; 48.38]
12.96 [3.47 ; 48.38 ] CheckMate 069 (BRAF wild type), 2015 1 0% 109 NA not evaluable objective responses (ORR) (extension)detailed results CheckMate 069 (BRAF wild type), 2015 13.00 [3.48; 48.60]
13.00 [3.48 ; 48.60 ] CheckMate 069 (BRAF wild type), 2015 1 0% 109 NA not evaluable TRAE leading to discontinuation (any grade)detailed results CheckMate 069 (BRAF wild type), 2015 3.39 [1.40; 8.19]
3.39 [1.40 ; 8.19 ] CheckMate 069 (BRAF wild type), 2015 1 0% 108 NA not evaluable 0.2 20.0 1.0 relative treatment effect www.metaEvidence.org 2024-10-03 06:40 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1;
studied treatment is better when TE < 1;
pathologies: 128
- treatments: 204,504,850,329,558,579,549,868,502,741,556,812,813,367,851,361,602,1070,671,865,744,696,1083,1281,1282,1283,1082,866,852,417,603,1051,876,853,1018,661,673,1049,1440,1561,854,374,953,672,1080,1560,1073,862,1562,1565,855,360,719,721,720,842,642,674,1085,863,503,847,982,359,575,577,576,869,1081,981,875,505,952,1021,1079,767,1071,1074,873,561,644,1251,1044,724,874,1043,1041,1042,940,1258,1563,746,745,856,634,861,416,864,769,980,369,743