All patients
Age < 65y (younger) Age > 65y BRAF mutant BRAF wild type ECOG 0 ECOG 1 Gender, female Gender, male LDH > ULN LDH ≤ULN previous systemic treatment (%) previous systemic treatment NO (%) stage IIIa stage IIIb stage IIIc stage M0/M1A/M1B stage M1C stage M1C (with brain metastasis)
Top evidence (RCT only, high risk of bias excluded)
Best available evidence (possibly low or very low)
All RCTs
All studies (RCT+OBS)
studies
metastatic/adv melanoma (mML), ipilimumab alone vs. pembrolizumab based treatment, meta-analysis of study results Outcome TE 95% CI n k I2 ROB Pub. bias deaths (OS)detailed results KEYNOTE-006 (2 week), 2015 (REV) 1.59 [1.19; 2.11]
KEYNOTE-006 (3 week), 2015 (REV) 1.45 [1.10; 1.91]
1.51 [1.24 ; 1.84 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,112 moderate not evaluable deaths (OS) (extension)detailed results KEYNOTE-006 (2 week), 2015 (REV) 1.47 [1.15; 1.88]
KEYNOTE-006 (3 week), 2015 (REV) 1.47 [1.15; 1.87]
1.47 [1.24 ; 1.75 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,112 moderate not evaluable PFS (extension)detailed results KEYNOTE-006 (2 week), 2015 (REV) 1.64 [1.34; 2.01]
KEYNOTE-006 (3 week), 2015 (REV) 1.64 [1.34; 2.01]
1.64 [1.42 ; 1.89 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,112 moderate not evaluable progression or deaths (PFS)detailed results KEYNOTE-006 (2 week), 2015 (REV) 1.72 [1.38; 2.16]
KEYNOTE-006 (3 week), 2015 (REV) 1.72 [1.39; 2.13]
1.72 [1.48 ; 2.01 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,112 moderate not evaluable objective responses (ORR)detailed results KEYNOTE-006 (2 week), 2015 (REV) 0.27 [0.17; 0.41]
KEYNOTE-006 (3 week), 2015 (REV) 0.28 [0.18; 0.43]
0.27 [0.20 ; 0.37 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,112 moderate not evaluable STRAE (any grade)detailed results KEYNOTE-006 (2 week), 2015 (REV) 1.49 [0.92; 2.42]
KEYNOTE-006 (3 week), 2015 (REV) 1.59 [0.97; 2.60]
1.54 [1.09 ; 2.17 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable STRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 1.09 [0.02; 54.94]
KEYNOTE-006 (3 week), 2015 (REV) 1.08 [0.02; 54.74]
1.08 [0.07 ; 17.38 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable TRAE (any grade)detailed results KEYNOTE-006 (2 week), 2015 (REV) 0.62 [0.41; 0.93]
KEYNOTE-006 (3 week), 2015 (REV) 0.86 [0.58; 1.28]
0.73 [0.53 ; 1.02 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 25% 1,067 moderate not evaluable TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 1.19 [0.77; 1.85]
KEYNOTE-006 (3 week), 2015 (REV) 1.22 [0.78; 1.90]
1.21 [0.88 ; 1.65 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable TRAE leading to death (grade 5)detailed results KEYNOTE-006 (2 week), 2015 (REV) 0.54 [0.02; 16.23]
KEYNOTE-006 (3 week), 2015 (REV) 1.08 [0.02; 54.74]
0.73 [0.06 ; 9.52 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable TRAE leading to discontinuation (any grade)detailed results KEYNOTE-006 (2 week), 2015 (REV) 1.35 [0.71; 2.53]
KEYNOTE-006 (3 week), 2015 (REV) 0.81 [0.46; 1.44]
1.03 [0.63 ; 1.68 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 25% 1,067 moderate not evaluable TRAE leading to discontinuation (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 1.09 [0.02; 54.94]
KEYNOTE-006 (3 week), 2015 (REV) 1.08 [0.02; 54.74]
1.08 [0.07 ; 17.38 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Abdominal pain TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 1.09 [0.02; 54.94]
KEYNOTE-006 (3 week), 2015 (REV) 1.08 [0.02; 54.74]
1.08 [0.07 ; 17.38 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Alopecia TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 1.09 [0.02; 54.94]
KEYNOTE-006 (3 week), 2015 (REV) 1.08 [0.02; 54.74]
1.08 [0.07 ; 17.38 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Anaemia TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 0.54 [0.05; 6.00]
KEYNOTE-006 (3 week), 2015 (REV) 2.17 [0.07; 64.92]
0.86 [0.12 ; 6.13 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Arthralgia TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 1.09 [0.02; 54.94]
KEYNOTE-006 (3 week), 2015 (REV) 1.08 [0.02; 54.74]
1.08 [0.07 ; 17.38 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Asthenia TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 2.18 [0.20; 24.20]
KEYNOTE-006 (3 week), 2015 (REV) 4.35 [0.20; 97.02]
2.83 [0.42 ; 18.94 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Chills TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 1.09 [0.02; 54.94]
KEYNOTE-006 (3 week), 2015 (REV) 1.08 [0.02; 54.74]
1.08 [0.07 ; 17.38 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Colitis TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 5.18 [1.73; 15.52]
KEYNOTE-006 (3 week), 2015 (REV) 2.92 [1.20; 7.11]
3.66 [1.84 ; 7.32 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Constipation TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 1.09 [0.02; 54.94]
KEYNOTE-006 (3 week), 2015 (REV) 1.08 [0.02; 54.74]
1.08 [0.07 ; 17.38 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Cough TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 1.09 [0.02; 54.94]
KEYNOTE-006 (3 week), 2015 (REV) 1.08 [0.02; 54.74]
1.08 [0.07 ; 17.38 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Decreased appetite TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 1.09 [0.02; 54.94]
KEYNOTE-006 (3 week), 2015 (REV) 1.08 [0.02; 54.74]
1.08 [0.07 ; 17.38 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Diabetes TRAE (grade 3-4)detailed results KEYNOTE-006 (3 week), 2015 (REV) 0.54 [0.02; 16.17]
0.54 [0.02 ; 16.17 ] KEYNOTE-006 (3 week), 2015 (REV) 1 0% 533 NA not evaluable Diarrhoea TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 1.09 [0.38; 3.15]
KEYNOTE-006 (3 week), 2015 (REV) 2.57 [0.66; 10.04]
1.50 [0.65 ; 3.48 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Dry skin TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 1.09 [0.02; 54.94]
KEYNOTE-006 (3 week), 2015 (REV) 1.08 [0.02; 54.74]
1.08 [0.07 ; 17.38 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Dyspnoea TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 2.18 [0.07; 65.16]
KEYNOTE-006 (3 week), 2015 (REV) 1.08 [0.07; 17.40]
1.43 [0.17 ; 12.30 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Fatigue TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 3.28 [0.34; 31.78]
KEYNOTE-006 (3 week), 2015 (REV) 1.08 [0.22; 5.41]
1.57 [0.42 ; 5.83 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Headache TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 1.09 [0.02; 54.94]
KEYNOTE-006 (3 week), 2015 (REV) 1.08 [0.02; 54.74]
1.08 [0.07 ; 17.38 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Hepatitis TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 0.36 [0.04; 3.48]
KEYNOTE-006 (3 week), 2015 (REV) 0.21 [0.02; 1.84]
0.27 [0.06 ; 1.30 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Hyperthyroidism TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 2.18 [0.07; 65.16]
KEYNOTE-006 (3 week), 2015 (REV) 2.17 [0.07; 64.92]
2.17 [0.20 ; 24.03 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Hypophysitis TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 4.37 [0.20; 97.37]
KEYNOTE-006 (3 week), 2015 (REV) 2.17 [0.20; 24.11]
2.82 [0.42 ; 18.92 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Hypothyroidism TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 0.54 [0.02; 16.23]
KEYNOTE-006 (3 week), 2015 (REV) 1.08 [0.02; 54.74]
0.73 [0.06 ; 9.52 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Increase AST TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 4.37 [0.20; 97.37]
KEYNOTE-006 (3 week), 2015 (REV) 2.17 [0.20; 24.11]
2.82 [0.42 ; 18.92 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Increased ALT TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 4.37 [0.20; 97.37]
KEYNOTE-006 (3 week), 2015 (REV) 2.17 [0.20; 24.11]
2.82 [0.42 ; 18.92 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Maculopapular rash TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 2.18 [0.07; 65.16]
KEYNOTE-006 (3 week), 2015 (REV) 1.08 [0.07; 17.40]
1.43 [0.17 ; 12.30 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Myalgia TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 1.09 [0.07; 17.46]
KEYNOTE-006 (3 week), 2015 (REV) 2.17 [0.07; 64.92]
1.43 [0.17 ; 12.31 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Myositis TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 1.09 [0.02; 54.94]
KEYNOTE-006 (3 week), 2015 (REV) 1.08 [0.02; 54.74]
1.08 [0.07 ; 17.38 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Nausea TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 1.09 [0.02; 54.94]
KEYNOTE-006 (3 week), 2015 (REV) 1.08 [0.02; 54.74]
1.08 [0.07 ; 17.38 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Nephritis TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 2.18 [0.07; 65.16]
KEYNOTE-006 (3 week), 2015 (REV) 2.17 [0.07; 64.92]
2.17 [0.20 ; 24.03 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Neutropenia TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 1.09 [0.02; 54.94]
KEYNOTE-006 (3 week), 2015 (REV) 1.08 [0.02; 54.74]
1.08 [0.07 ; 17.38 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Paraesthesia TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 2.18 [0.07; 65.16]
KEYNOTE-006 (3 week), 2015 (REV) 2.17 [0.07; 64.92]
2.17 [0.20 ; 24.03 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Pneumonitis TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 2.18 [0.07; 65.16]
KEYNOTE-006 (3 week), 2015 (REV) 1.08 [0.07; 17.40]
1.43 [0.17 ; 12.30 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Pruritic rash TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 1.09 [0.02; 54.94]
KEYNOTE-006 (3 week), 2015 (REV) 1.08 [0.02; 54.74]
1.08 [0.07 ; 17.38 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Pruritus TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 1.09 [0.02; 54.94]
KEYNOTE-006 (3 week), 2015 (REV) 1.08 [0.02; 54.74]
1.08 [0.07 ; 17.38 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Pyrexia TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 1.09 [0.02; 54.94]
KEYNOTE-006 (3 week), 2015 (REV) 1.08 [0.02; 54.74]
1.08 [0.07 ; 17.38 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Rash TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 1.09 [0.02; 54.94]
KEYNOTE-006 (3 week), 2015 (REV) 1.08 [0.02; 54.74]
1.08 [0.07 ; 17.38 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Uveitis TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 1.09 [0.02; 54.94]
KEYNOTE-006 (3 week), 2015 (REV) 1.08 [0.02; 54.74]
1.08 [0.07 ; 17.38 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Vomiting TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 0.54 [0.02; 16.23]
KEYNOTE-006 (3 week), 2015 (REV) 1.08 [0.02; 54.74]
0.73 [0.06 ; 9.52 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable Weight decreased TRAE (grade 3-4)detailed results KEYNOTE-006 (2 week), 2015 (REV) 2.18 [0.07; 65.16]
KEYNOTE-006 (3 week), 2015 (REV) 2.17 [0.07; 64.92]
2.17 [0.20 ; 24.03 ] KEYNOTE-006 (2 week), 2015 (REV), KEYNOTE-006 (3 week), 2015 (REV) 2 0% 1,067 moderate not evaluable 0.2 5.0 1.0 relative treatment effect www.metaEvidence.org 2024-10-02 16:10 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1;
studied treatment is better when TE < 1;
pathologies: 283,284,70,235,285,68,127,128,286,69,129
- treatments: 329,558