All patients
Age < 65y (younger) Age > 65y Asian type cell type, squamous cell ECOG 0 ECOG 1 EGFR mutation Ex19del EGFR mutation L858R Gender, female Gender, male smoker (current or former) smoker (never)
Top evidence (RCT only, high risk of bias excluded)
Best available evidence (possibly low or very low)
All RCTs
All studies (RCT+OBS)
studies
lung cancer : non small cell (NSCLC), ... vs. platinum association, meta-analysis of study results Outcome TE 95% CI n k I2 ROB Pub. bias deaths (OS)detailed results LUX-LUNG 3, 2013 1.12 [0.73; 1.72]
LUX-LUNG 6, 2014 0.95 [0.68; 1.33]
1.01 [0.78 ; 1.32 ] LUX-LUNG 3, 2013, LUX-LUNG 6, 2014 2 0% 709 moderate not evaluable progression or deaths (PFS)detailed results LUX-LUNG 3, 2013 0.47 [0.34; 0.65]
LUX-LUNG 6, 2014 0.28 [0.20; 0.39]
0.36 [0.22 ; 0.60 ] LUX-LUNG 3, 2013, LUX-LUNG 6, 2014 2 79% 709 moderate not evaluable DCRdetailed results LUX-LUNG 6, 2014 3.84 [2.04; 7.23]
3.84 [2.04 ; 7.23 ] LUX-LUNG 6, 2014 1 0% 364 NA not evaluable objective responses (ORR)detailed results LUX-LUNG 3, 2013 4.37 [2.63; 7.27]
LUX-LUNG 6, 2014 6.53 [4.02; 10.60]
5.38 [3.64 ; 7.98 ] LUX-LUNG 3, 2013, LUX-LUNG 6, 2014 2 20% 709 moderate not evaluable TRAE (any grade)detailed results LUX-LUNG 6, 2014 0.70 [0.07; 6.83]
0.70 [0.07 ; 6.83 ] LUX-LUNG 6, 2014 1 0% 352 NA not evaluable TRAE (grade 3-4)detailed results LUX-LUNG 3, 2013 0.98 [0.62; 1.54]
LUX-LUNG 6, 2014 0.38 [0.24; 0.60]
0.61 [0.24 ; 1.54 ] LUX-LUNG 3, 2013, LUX-LUNG 6, 2014 2 88% 692 moderate not evaluable TRAE leading to death (grade 5)detailed results LUX-LUNG 3, 2013 3.93 [0.21; 74.98]
LUX-LUNG 6, 2014 0.47 [0.03; 7.59]
1.28 [0.16 ; 10.22 ] LUX-LUNG 3, 2013, LUX-LUNG 6, 2014 2 5% 692 moderate not evaluable TRAE leading to discontinuation (any grade)detailed results LUX-LUNG 3, 2013 0.74 [0.36; 1.50]
LUX-LUNG 6, 2014 0.09 [0.05; 0.18]
0.26 [0.03 ; 1.97 ] LUX-LUNG 3, 2013, LUX-LUNG 6, 2014 2 94% 692 moderate not evaluable 0.2 10.0 1.0 relative treatment effect www.metaEvidence.org 2024-10-06 19:38 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1;
studied treatment is better when TE < 1;
pathologies: 161,226,41,225,182,198,179,200,195,254,242,243,199,190,229,266,191,196,36,228,174,171,173,307,165,163,176,308,164,166,220,197,255,37,245,204,244,241,227,217,177,279,167,1,170,261,280,168,169,335,334
- treatments: 472