All patients
Age < 65y (younger) Age > 65y Age > 75y (older) Asian type BRAF mutant BRAF wild type dMMR ECOG 0 ECOG 1 Gender, female Gender, male PD-L1 < 1% PD-L1 > 1% RAS mutant RAS wild type
Top evidence (RCT only, high risk of bias excluded)
Best available evidence (possibly low or very low)
All RCTs
All studies (RCT+OBS)
studies
colorectal cancer (CRC), immune chekpoint inhibitors vs. BSC, meta-analysis of study results Outcome TE 95% CI n k I2 ROB Pub. bias deaths (OS)detailed results CO.26 study, 2020 0.72 [0.54; 0.96]
0.72 [0.54 ; 0.96 ] CO.26 study, 2020 1 0% 180 NA not evaluable progression or deaths (PFS)detailed results CO.26 study, 2020 1.01 [0.76; 1.34]
1.01 [0.76 ; 1.34 ] CO.26 study, 2020 1 0% 180 NA not evaluable DCRdetailed results CO.26 study, 2020 4.16 [1.40; 12.33]
4.16 [1.40 ; 12.33 ] CO.26 study, 2020 1 0% 180 NA not evaluable objective responses (ORR)detailed results CO.26 study, 2020 1.03 [0.03; 31.00]
1.03 [0.03 ; 31.00 ] CO.26 study, 2020 1 0% 180 NA not evaluable AE (any grade)detailed results CO.26 study, 2020 40.67 [2.31; 714.82]
40.67 [2.31 ; 714.82 ] CO.26 study, 2020 1 0% 179 NA not evaluable 0.5 100.0 1.0 relative treatment effect www.metaEvidence.org 2024-09-30 17:48 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1;
studied treatment is better when TE < 1;
pathologies: 126,385,183,384,137,138
- treatments: 204,504,850,329,558,579,549,868,502,741,556,812,813,367,851,361,602,1070,671,865,744,696,1083,1281,1282,1283,1082,866,852,417,603,1051,876,853,1018,661,673,1049,1440,1561,854,374,953,672,1080,1560,1073,862,1562,1565,855,360,719,721,720,842,642,674,1085,863,503,847,982,359,575,577,576,869,1081,981,875,505,952,1021,1079,767,1071,1074,873,561,644,1251,1044,724,874,1043,1041,1042,940,1258,1563,746,745,856,634,861,416,864,769,980,369,743