All patients
Age < 65y (younger) Age > 65y Age > 75y (older) Asian type cell type, non squamous cell cell type, squamous cell ECOG 0 ECOG 1 Gender, female Gender, male PDL1 (TC1/2 or IC1/2 : ≥1% of TC or IC and <50% of TC and <10% of IC) PDL1 (TC3 or IC3 : ≥50% of TC or ≥10% of IC ) smoker (current or former) smoker (never)
Top evidence (RCT only, high risk of bias excluded)
Best available evidence (possibly low or very low)
All RCTs
All studies (RCT+OBS)
studies
mNSCLC - L2 - PDL1 positive, anti-PD-(L)1 vs. taxanes, meta-analysis of study results Outcome TE 95% CI n k I2 ROB Pub. bias deaths (OS)detailed results JAVELIN Lung 200 (PDL1 >1%), 2018 0.90 [0.72; 1.12]
OAK (PDL1 TC 1/2/3), 2016 0.77 [0.64; 0.92]
0.82 [0.71 ; 0.96 ] JAVELIN Lung 200 (PDL1 >1%), 2018, OAK (PDL1 TC 1/2/3), 2016 2 13% 1,213 moderate not evaluable progression or deaths (PFS)detailed results JAVELIN Lung 200 (PDL1 >1%), 2018 1.01 [0.80; 1.28]
OAK (PDL1 TC 1/2/3), 2016 0.87 [0.74; 1.03]
0.92 [0.80 ; 1.05 ] JAVELIN Lung 200 (PDL1 >1%), 2018, OAK (PDL1 TC 1/2/3), 2016 2 3% 1,213 moderate not evaluable DORdetailed results OAK (PDL1 TC 1/2/3), 2016 9.61 [3.07; 30.08]
9.61 [3.07 ; 30.08 ] OAK (PDL1 TC 1/2/3), 2016 1 0% 107 NA not evaluable objective responses (ORR)detailed results JAVELIN Lung 200 (PDL1 >1%), 2018 1.76 [1.08; 2.86]
OAK (PDL1 TC 1/2/3), 2016 1.41 [0.93; 2.14]
1.55 [1.13 ; 2.13 ] JAVELIN Lung 200 (PDL1 >1%), 2018, OAK (PDL1 TC 1/2/3), 2016 2 0% 1,213 moderate not evaluable 0.5 20.0 1.0 relative treatment effect www.metaEvidence.org 2024-10-05 01:03 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1;
studied treatment is better when TE < 1;
pathologies: 177
- treatments: 367,851,361,602,1070,671,865,744,696,1083,1281,1282,1283,1082,866,852,417,603,1051,876,853,1018,661,673,1049,1440,1561,854,374,953,672,1080,1560,1073,862,1562,1565,855,360,719,721,720,842,642,674,1085,863,503,847,982,359,575,577,576,869,1081,981,875,505,952,1021,1079,767,1071,1074,873,561,644,1251,1044,724,874,1043,1041,1042,940,1258,1563