All patients
Age < 65y (younger) Age > 65y Asian type cell type, adenocarcinoma cell cell type, non squamous cell cell type, squamous cell ECOG ⩾ 1 ECOG 0 ECOG 1 EGFR mutant EGFR mutation Ex19del EGFR mutation L858R EGFR negative EGFR positive EGFR wild type Gender, female Gender, male RAS mutant RAS wild type smoker (current or former) smoker (Current) smoker (Former) smoker (never) stage I stage II stage IIIa stage IIIb stage IV (metastatic)
Top evidence (RCT only, high risk of bias excluded)
Best available evidence (possibly low or very low)
All RCTs
All studies (RCT+OBS)
studies
lung cancer : non small cell (NSCLC), ... vs. non active control, meta-analysis of study results Outcome TE 95% CI n k I2 ROB Pub. bias deaths (OS)detailed results NCIC CTG BR.21, 2005 0.70 [0.58; 0.85]
RADIANT, 2015 1.13 [0.88; 1.45]
TOPICAL, 2012 0.92 [0.79; 1.08]
0.89 [0.69 ; 1.14 ] NCIC CTG BR.21, 2005, RADIANT, 2015, TOPICAL, 2012 3 79% 2,374 moderate not evaluable progression or deaths (PFS)detailed results NCIC CTG BR.21, 2005 0.61 [0.51; 0.73]
TOPICAL, 2012 0.80 [0.68; 0.94]
0.70 [0.54 ; 0.92 ] NCIC CTG BR.21, 2005, TOPICAL, 2012 2 79% 1,401 low not evaluable events or deaths (EFS)detailed results RADIANT, 2015 0.90 [0.74; 1.10]
0.90 [0.74 ; 1.10 ] RADIANT, 2015 1 0% 973 NA not evaluable objective responses (ORR)detailed results NCIC CTG BR.21, 2005 10.18 [2.43; 42.54]
TOPICAL, 2012 2.00 [0.81; 4.98]
4.09 [0.84 ; 19.91 ] NCIC CTG BR.21, 2005, TOPICAL, 2012 2 72% 1,401 low not evaluable 0.5 10.0 1.0 relative treatment effect www.metaEvidence.org 2024-09-30 11:09 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1;
studied treatment is better when TE < 1;
pathologies: 161,226,41,225,182,198,179,200,195,254,242,243,199,190,229,266,191,196,36,228,174,171,173,307,165,163,176,308,164,166,220,197,255,37,245,204,244,241,227,217,177,279,167,1,170,261,280,168,169,335,334
- treatments: 430