All patients
Age < 65y (younger) Age > 65y Age > 75y (older) Asian type cancer type (metastatic) cancer type (recurrent) ECOG 0 ECOG 1 Gender, female Gender, male P16 negative (HPV) P16 positive (HPV) PD-L1 < 1% PD-L1 < 10% PD-L1 < 5% PD-L1 > 1% PD-L1 > 10% PD-L1 > 5% PDL1 (CPS < 1) PDL1 (CPS >1) PDL1 (TPS <50%) PDL1 (TPS >50%) PDL1 < 25% PDL1 >25% smoker (current or former) smoker (Current) smoker (Former) smoker (never)
Top evidence (RCT only, high risk of bias excluded)
Best available evidence (possibly low or very low)
All RCTs
All studies (RCT+OBS)
studies
head and neck cancer squamous cell cancer (HNSCC), anti-PD-(L)1 vs. non active control, meta-analysis of study results Outcome TE 95% CI n k I2 ROB Pub. bias deaths (OS)detailed results JAVELIN Head and Neck 100, 2021 1.31 [0.93; 1.85]
1.31 [0.93 ; 1.85 ] JAVELIN Head and Neck 100, 2021 1 0% 697 NA not evaluable progression or deaths (PFS)detailed results JAVELIN Head and Neck 100, 2021 1.21 [0.93; 1.57]
1.21 [0.93 ; 1.57 ] JAVELIN Head and Neck 100, 2021 1 0% 697 NA not evaluable objective responses (ORR)detailed results JAVELIN Head and Neck 100, 2021 0.95 [0.66; 1.36]
0.95 [0.66 ; 1.36 ] JAVELIN Head and Neck 100, 2021 1 0% 697 NA not evaluable AE (any grade)detailed results JAVELIN Head and Neck 100, 2021 0.67 [0.11; 4.05]
0.67 [0.11 ; 4.05 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable AE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.54 [1.02; 2.33]
1.54 [1.02 ; 2.33 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable STRAE (any grade)detailed results JAVELIN Head and Neck 100, 2021 1.19 [0.87; 1.64]
1.19 [0.87 ; 1.64 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable TRAE (any grade)detailed results JAVELIN Head and Neck 100, 2021 0.67 [0.19; 2.40]
0.67 [0.19 ; 2.40 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.38 [0.97; 1.97]
1.38 [0.97 ; 1.97 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable TRAE leading to death (grade 5)detailed results JAVELIN Head and Neck 100, 2021 1.98 [0.18; 21.97]
1.98 [0.18 ; 21.97 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Abdominal pain TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.49 [0.02; 14.76]
0.49 [0.02 ; 14.76 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Acute kidney injury TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.24 [0.48; 3.19]
1.24 [0.48 ; 3.19 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Adrenal insufficiency TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.49 [0.02; 14.76]
0.49 [0.02 ; 14.76 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Anaemia TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.91 [0.58; 1.43]
0.91 [0.58 ; 1.43 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Asthenia TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.50 [0.61; 3.72]
1.50 [0.61 ; 3.72 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Blood creatinine increased TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.39 [0.44; 4.43]
1.39 [0.44 ; 4.43 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Chills TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.98 [0.07; 59.21]
1.98 [0.07 ; 59.21 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Colitis TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.25 [0.01; 5.48]
0.25 [0.01 ; 5.48 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Constipation TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.98 [0.07; 59.21]
1.98 [0.07 ; 59.21 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Cough TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.98 [0.07; 59.21]
1.98 [0.07 ; 59.21 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Decreased appetite TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.36 [0.71; 2.60]
1.36 [0.71 ; 2.60 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Diarrhoea TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.99 [0.14; 7.06]
0.99 [0.14 ; 7.06 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Dysgeusia TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.25 [0.01; 5.48]
0.25 [0.01 ; 5.48 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Dysphonia TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.99 [0.02; 49.96]
0.99 [0.02 ; 49.96 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Fatigue TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.16 [0.53; 2.54]
1.16 [0.53 ; 2.54 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Febrile neutropenia TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.76 [0.28; 2.08]
0.76 [0.28 ; 2.08 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Headache TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.98 [0.07; 59.21]
1.98 [0.07 ; 59.21 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Hypertension TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.99 [0.36; 10.93]
1.99 [0.36 ; 10.93 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Hyperthyroidism TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.98 [0.18; 21.97]
1.98 [0.18 ; 21.97 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Hypothyroidism TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.99 [0.02; 49.96]
0.99 [0.02 ; 49.96 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Increase AST TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.98 [0.18; 21.97]
1.98 [0.18 ; 21.97 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Increased ALT TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 7.04 [0.86; 57.54]
7.04 [0.86 ; 57.54 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Increased lipase level TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 5.00 [0.58; 43.02]
5.00 [0.58 ; 43.02 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Infusion-related reactions TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 3.97 [0.18; 88.38]
3.97 [0.18 ; 88.38 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Leucopenia TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.04 [0.55; 1.96]
1.04 [0.55 ; 1.96 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Mucosal inflammation TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.11 [0.72; 1.72]
1.11 [0.72 ; 1.72 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Nausea TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.30 [0.68; 2.49]
1.30 [0.68 ; 2.49 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Nephritis TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.98 [0.07; 59.21]
1.98 [0.07 ; 59.21 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Neutropenia TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.10 [0.73; 1.66]
1.10 [0.73 ; 1.66 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Pancytopenia TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.98 [0.07; 59.21]
1.98 [0.07 ; 59.21 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Peripheral neuropathy TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.25 [0.01; 5.48]
0.25 [0.01 ; 5.48 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Peripheral oedema TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.49 [0.02; 14.76]
0.49 [0.02 ; 14.76 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Pneumonia TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.76 [0.28; 2.08]
0.76 [0.28 ; 2.08 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Pneumonitis TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 10.01 [0.55; 184.02]
10.01 [0.55 ; 184.02 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Pyrexia TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.49 [0.04; 5.46]
0.49 [0.04 ; 5.46 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Rash TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.98 [0.07; 59.21]
1.98 [0.07 ; 59.21 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Sepsis TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.49 [0.04; 5.46]
0.49 [0.04 ; 5.46 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Stomatitis TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.99 [0.56; 1.74]
0.99 [0.56 ; 1.74 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Thrombocytopenia TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 9.31 [3.63; 23.82]
9.31 [3.63 ; 23.82 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Urticaria TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.98 [0.07; 59.21]
1.98 [0.07 ; 59.21 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Vomiting TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.88 [0.46; 1.70]
0.88 [0.46 ; 1.70 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Weight decreased TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.66 [0.34; 1.29]
0.66 [0.34 ; 1.29 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable 0.0 20.0 1.0 relative treatment effect www.metaEvidence.org 2024-10-03 14:41 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1;
studied treatment is better when TE < 1;
pathologies: 6,275,106,104,105,276,103,277,102,109,278,101,192,114
- treatments: 367,851,361,602,1070,671,865,744,696,1083,1281,1282,1283,1082,866,852,417,603,1051,876,853,1018,661,673,1049,1440,1561,854,374,953,672,1080,1560,1073,862,1562,1565,855,360,719,721,720,842,642,674,1085,863,503,847,982,359,575,577,576,869,1081,981,875,505,952,1021,1079,767,1071,1074,873,561,644,1251,1044,724,874,1043,1041,1042,940,1258,1563