All patients
Age < 65y (younger) Age > 65y Age > 75y (older) Asian type cell type, non squamous cell cell type, squamous cell ECOG 0 ECOG 1 EGFR mutant Gender, female Gender, male metastasis (brain) NO metastasis (brain) YES metastasis (liver ) PDL1 (TC0 and IC0 : <1% of TC and IC) PDL1 (TC1/2 or IC1/2 : ≥1% of TC or IC and <50% of TC and <10% of IC) PDL1 (TC1/2/3 or IC1/2/3 : ≥1% of TC or IC) PDL1 (TC2/3 or IC2/3 : ≥5% of TC or IC) PDL1 (TC3 or IC3 : ≥50% of TC or ≥10% of IC ) smoker (current or former) smoker (Current) smoker (Former) smoker (never) Teff high Teff low
Top evidence (RCT only, high risk of bias excluded)
Best available evidence (possibly low or very low)
All RCTs
All studies (RCT+OBS)
studies
lung cancer : non small cell (NSCLC), atezolizumab based treatment vs. Standard of Care (SoC), meta-analysis of study results Outcome TE 95% CI n k I2 ROB Pub. bias deaths (OS)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.83 [0.65; 1.06]
IMpower-110 (TC2/3 or IC2/3), 2020 0.72 [0.52; 0.99]
IMpower-110 (TC3 or IC3), 2020 0.59 [0.40; 0.88]
0.74 [0.62 ; 0.89 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020, IMpower-110 (TC2/3 or IC2/3), 2020, IMpower-110 (TC3 or IC3), 2020 3 3% 1,087 moderate not evaluable deaths (OS) (extension)detailed results IMpower-110 (TC3 or IC3), 2020 0.76 [0.53; 1.08]
0.76 [0.53 ; 1.08 ] IMpower-110 (TC3 or IC3), 2020 1 0% 205 NA not evaluable PFS (extension)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.72 [0.60; 0.86]
IMpower-110 (TC2/3 or IC2/3), 2020 0.64 [0.50; 0.82]
IMpower-110 (TC3 or IC3), 2020 0.59 [0.43; 0.81]
0.67 [0.59 ; 0.77 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020, IMpower-110 (TC2/3 or IC2/3), 2020, IMpower-110 (TC3 or IC3), 2020 3 0% 1,087 moderate not evaluable progression or deaths (PFS)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.77 [0.63; 0.94]
IMpower-110 (TC2/3 or IC2/3), 2020 0.67 [0.52; 0.87]
IMpower-110 (TC3 or IC3), 2020 0.63 [0.45; 0.88]
0.71 [0.62 ; 0.82 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020, IMpower-110 (TC2/3 or IC2/3), 2020, IMpower-110 (TC3 or IC3), 2020 3 0% 1,087 moderate not evaluable objective responses (ORR)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.89 [0.62; 1.27]
IMpower-110 (TC2/3 or IC2/3), 2020 0.94 [0.59; 1.50]
IMpower-110 (TC3 or IC3), 2020 1.55 [0.86; 2.79]
1.02 [0.76 ; 1.39 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020, IMpower-110 (TC2/3 or IC2/3), 2020, IMpower-110 (TC3 or IC3), 2020 3 25% 1,087 moderate not evaluable objective responses (ORR) (extension)detailed results IMpower-110 (TC3 or IC3), 2020 1.68 [0.94; 3.01]
1.68 [0.94 ; 3.01 ] IMpower-110 (TC3 or IC3), 2020 1 0% 205 NA not evaluable AE (any grade)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.52 [0.27; 1.01]
0.52 [0.27 ; 1.01 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable AE (grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.39 [0.27; 0.55]
0.39 [0.27 ; 0.55 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable AE leading to death (grade 5)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.92 [0.39; 2.15]
0.92 [0.39 ; 2.15 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable AE leading to treatment discontinuation (any grade)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.34 [0.19; 0.61]
0.34 [0.19 ; 0.61 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable SAE (any grade)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.99 [0.68; 1.44]
0.99 [0.68 ; 1.44 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable STRAE (any grade)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.50 [0.29; 0.85]
0.50 [0.29 ; 0.85 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable TRAE (any grade)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.27 [0.18; 0.40]
0.27 [0.18 ; 0.40 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable TRAE (grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.19 [0.12; 0.29]
0.19 [0.12 ; 0.29 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable TRAE leading to death (grade 5)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.46 [0.02; 13.73]
0.46 [0.02 ; 13.73 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable Colitis TRAE (grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 3.70 [0.17; 82.36]
3.70 [0.17 ; 82.36 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable Hepatitis TRAE (grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 11.47 [1.48; 88.87]
11.47 [1.48 ; 88.87 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable Hyperthyroidism TRAE (grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.92 [0.02; 46.51]
0.92 [0.02 ; 46.51 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable Hypothyroidism TRAE (grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.92 [0.02; 46.51]
0.92 [0.02 ; 46.51 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable Infusion-related reactions TRAE (grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.92 [0.02; 46.51]
0.92 [0.02 ; 46.51 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable Pneumonitis TRAE (grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 3.70 [0.17; 82.36]
3.70 [0.17 ; 82.36 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable Rash TRAE (grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1.38 [0.23; 8.34]
1.38 [0.23 ; 8.34 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable Anaemia AE (grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.08 [0.03; 0.20]
0.08 [0.03 ; 0.20 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable Asthenia AE (grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.36 [0.07; 1.89]
0.36 [0.07 ; 1.89 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable Constipation AE (grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1.38 [0.23; 8.34]
1.38 [0.23 ; 8.34 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable Cough AE (grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1.84 [0.06; 55.14]
1.84 [0.06 ; 55.14 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable Decreased appetite AE (grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 3.70 [0.17; 82.36]
3.70 [0.17 ; 82.36 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable Diarrhoea AE (grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.23 [0.01; 5.09]
0.23 [0.01 ; 5.09 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable Dyspnoea AE (grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 3.70 [0.17; 82.36]
3.70 [0.17 ; 82.36 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable Fatigue AE (grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.30 [0.06; 1.51]
0.30 [0.06 ; 1.51 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable Febrile neutropenia AE (grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.05 [0.00; 0.86]
0.05 [0.00 ; 0.86 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable Hypertension AE (grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.61 [0.10; 3.68]
0.61 [0.10 ; 3.68 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable Increase AST AE (grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 4.66 [0.54; 40.17]
4.66 [0.54 ; 40.17 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable Increased ALT AE (grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 4.66 [0.54; 40.17]
4.66 [0.54 ; 40.17 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable Leucopenia AE (grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.23 [0.03; 2.05]
0.23 [0.03 ; 2.05 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable Nausea AE (grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.18 [0.02; 1.56]
0.18 [0.02 ; 1.56 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable Neutropenia AE (grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.03 [0.01; 0.14]
0.03 [0.01 ; 0.14 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable Pancytopenia (AE grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.46 [0.04; 5.08]
0.46 [0.04 ; 5.08 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable Pneumonia AE (grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.71 [0.26; 1.93]
0.71 [0.26 ; 1.93 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable Pyrexia AE (grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.46 [0.02; 13.73]
0.46 [0.02 ; 13.73 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable Sepsis AE (grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.46 [0.04; 5.08]
0.46 [0.04 ; 5.08 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable Thrombocytopenia AE (grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.05 [0.01; 0.34]
0.05 [0.01 ; 0.34 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable Vomiting AE (grade 3-4)detailed results IMpower-110 (TC1/2/3 or IC1/2/3), 2020 0.46 [0.04; 5.08]
0.46 [0.04 ; 5.08 ] IMpower-110 (TC1/2/3 or IC1/2/3), 2020 1 0% 549 NA not evaluable 0.0 20.0 1.0 relative treatment effect www.metaEvidence.org 2024-09-30 13:08 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1;
studied treatment is better when TE < 1;
pathologies: 161,226,41,225,182,198,179,200,195,254,242,243,199,190,229,266,191,196,36,228,174,171,173,307,165,163,176,308,164,166,220,197,255,37,245,204,244,241,227,217,177,279,167,1,170,261,280,168,169,335,334
- treatments: 851,361,602,1070,671,865,744,696,1083,1281,1282,1283,1082,866