• metastatic/advanced hepatocellular cancer (mHCC)
• mHCC - (neo)adjuvant (NA)
• mHCC - 1st line (L1) 4
• mHCC - 2nd line (L2) 2
• lung cancer : non small cell (NSCLC) 5

 

• gene alteration target therapy
• BRAF gene alteration targeted therapy
• BRAF inhibitor
• combined BRAF-MEK inhibitors
• trametinib plus dabrafenib
• KRAS gene alteration targeted therapy
• sotorasib
• MET gene alteration targeted therapy
• capmatinib
• NTRK gene alteration targeted therapy
• entrectinib
• larotrectinib
• RET gene alteration targeted therapy
• pralsetinib
• selpercatinib
• immune chekpoint inhibitors
• anti-CTLA-4
• ipilimumab based treatment
• ipilimumab plus SoC
• anti-PD-(L)1
• atezolizumab based treatment
• atezolizumab alone
• atezolizumab plus bevacizumab plus carboplatin plus paclitaxel
• atezolizumab plus carboplatin plus nab-paclitaxel
• atezolizumab plus carboplatin plus paclitaxel
• atezolizumab plus pemetrexed and platin
• avelumab based treatment
• avelumab alone
• cemiplimab
• durvalumab based treatment
• durvalumab alone
• durvalumab plus osimertinib
• nivolumab based treatment
• nivolumab alone
• nivolumab plus SoC
• pembrolizumab based treatment
• pembrolizumab alone
• pembrolizumab (10mg/kg)
• pembrolizumab (2mg/kg)
• pembrolizumab and pemetrexed plus platin
• pembrolizumab plus SoC
• sintilimab based treatment
• sintillimab plus SoC
• Tislelizumab
• Immune checkpoint association
• durvalumab plus tremelimumab
• nivolumab plus ipilimumab
• nivolumab plus ipilimumab plus SoC
• pembrolizumab plus ipilimumab

• versus all
• vs chemotherapy
• vs non platinum-based chemotherapy
• vs taxanes
• vs docetaxel
• vs paclitaxel
• vs nab-paclitaxel
• vs platinum-based chemotherapy
• vs platinum derivate
• vs platinum association
• vs paclitaxel plus carboplatin
• vs carboplatin plus nab-paclitaxel
• vs pemetrexed plus platin
• vs Standard of Care (SoC)
• vs placebo plus SoC
• vs gene alteration target therapy
• vs EGFR gene alteration
• vs osimertinib
• vs immune chekpoint inhibitors
• vs anti-PD-(L)1
• vs atezolizumab based treatment
• vs atezolizumab plus carboplatin plus nab-paclitaxel
• vs pembrolizumab based treatment
• vs pembrolizumab alone
• vs pembrolizumab plus placebo
• vs non active control
• vs no control (uncontrolled study)
• vs placebo
• vs VEGF(R) inhibitor
• vs bevacizumab based treatment
• vs bevacizumab plus carboplatin and paclitaxel

  All patients Age < 65y (younger) Age > 65y Asian type cell type, adenocarcinoma cell cell type, non squamous cell cell type, squamous cell ECOG ⩾ 1 ECOG 0 ECOG 1 EGFR mutant EGFR mutation Ex19del EGFR mutation L858R EGFR negative EGFR positive EGFR wild type Gender, female Gender, male RAS mutant RAS wild type smoker (current or former) smoker (Current) smoker (Former) smoker (never) stage I stage II stage IIIa stage IIIb stage IV (metastatic)

• study list
• mapping
• overview
• meta-analysis
• forest plot
• NMA
• excluded

Top evidence (RCT only, high risk of bias excluded) Best available evidence (possibly low or very low) All RCTs All studies (RCT+OBS)   studies

lung cancer : non small cell (NSCLC), ... vs. placebo, meta-analysis of study results

TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers); k: number of studies; n: total number of patients; ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1; studied treatment is better when TE < 1;