All patients
Age < 65y (younger) Age > 65y ECOG 0 ECOG 1 Gender, female Gender, male LDH > ULN LDH ≤ULN PD-L1 < 1% PD-L1 > 1% stage IIIc stage IV (metastatic) stage M0 stage M1A stage M1B stage M1C
Top evidence (RCT only, high risk of bias excluded)
Best available evidence (possibly low or very low)
All RCTs
All studies (RCT+OBS)
studies
mML - L1 - BRAF mutant, immune chekpoint inhibitors vs. anti-CTLA-4, meta-analysis of study results Outcome TE 95% CI n k I2 ROB Pub. bias deaths (OS)detailed results CheckMate 069 (BRAF mutant) EXPLORATORY, 2015 1.44 [0.46; 4.49]
1.44 [0.46 ; 4.49 ] CheckMate 069 (BRAF mutant) EXPLORATORY, 2015 1 0% 33 NA not evaluable PFS (extension)detailed results CheckMate 069 (BRAF mutant) EXPLORATORY, 2015 0.47 [0.10; 2.27]
0.47 [0.10 ; 2.27 ] CheckMate 069 (BRAF mutant) EXPLORATORY, 2015 1 0% 33 NA not evaluable progression or deaths (PFS)detailed results CheckMate 069 (BRAF mutant) EXPLORATORY, 2015 0.38 [0.15; 0.98]
0.38 [0.15 ; 0.98 ] CheckMate 069 (BRAF mutant) EXPLORATORY, 2015 1 0% 33 NA not evaluable objective responses (ORR)detailed results CheckMate 069 (BRAF mutant) EXPLORATORY, 2015 9.82 [0.45; 212.91]
9.82 [0.45 ; 212.91 ] CheckMate 069 (BRAF mutant) EXPLORATORY, 2015 1 0% 33 NA not evaluable objective responses (ORR) (extension)detailed results CheckMate 069 (BRAF mutant) EXPLORATORY, 2015 9.80 [0.45; 211.42]
9.80 [0.45 ; 211.42 ] CheckMate 069 (BRAF mutant) EXPLORATORY, 2015 1 0% 33 NA not evaluable 0.2 20.0 1.0 relative treatment effect www.metaEvidence.org 2024-10-05 07:04 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1;
studied treatment is better when TE < 1;
pathologies: 127
- treatments: 204,504,850,329,558,579,549,868,502,741,556,812,813,367,851,361,602,1070,671,865,744,696,1083,1281,1282,1283,1082,866,852,417,603,1051,876,853,1018,661,673,1049,1440,1561,854,374,953,672,1080,1560,1073,862,1562,1565,855,360,719,721,720,842,642,674,1085,863,503,847,982,359,575,577,576,869,1081,981,875,505,952,1021,1079,767,1071,1074,873,561,644,1251,1044,724,874,1043,1041,1042,940,1258,1563,746,745,856,634,861,416,864,769,980,369,743