All patients
HER2 positive
Top evidence (RCT only, high risk of bias excluded)
Best available evidence (possibly low or very low)
All RCTs
All studies (RCT+OBS)
studies
la/mBC - HER2 positive, HER2 inhibitor vs. trastuzumab based treatment, meta-analysis of study results Outcome TE 95% CI n k I2 ROB Pub. bias deaths (OS)detailed results CLEOPATRA, 2012 0.66 [0.52; 0.84]
HER2CLIMB, 2020 0.66 [0.50; 0.88]
SYSUCC-002, 2022 0.82 [0.65; 1.04]
0.72 [0.62 ; 0.83 ] CLEOPATRA, 2012, HER2CLIMB, 2020, SYSUCC-002, 2022 3 2% 1,812 low not evaluable deaths (OS) (extension)detailed results CLEOPATRA, 2012 0.69 [0.58; 0.82]
0.69 [0.58 ; 0.82 ] CLEOPATRA, 2012 1 0% 808 NA not evaluable PFS (extension)detailed results CLEOPATRA, 2012 0.69 [0.59; 0.81]
0.69 [0.59 ; 0.81 ] CLEOPATRA, 2012 1 0% 808 NA not evaluable progression or deaths (PFS)detailed results CLEOPATRA, 2012 0.62 [0.51; 0.75]
HER2CLIMB, 2020 0.54 [0.42; 0.70]
HER2CLIMB (patients with brain metastases), 2020 0.48 [0.34; 0.68]
SYSUCC-002, 2022 0.88 [0.71; 1.09]
0.63 [0.49 ; 0.81 ] CLEOPATRA, 2012, HER2CLIMB, 2020, HER2CLIMB (patients with brain metastases), 2020, SYSUCC-002, 2022 4 76% 1,971 low not evaluable objective responses (ORR)detailed results CLEOPATRA, 2012 10.80 [5.29; 22.05]
10.80 [5.29 ; 22.05 ] CLEOPATRA, 2012 1 0% 679 NA not evaluable AE leading to treatment discontinuation (any grade)detailed results HER2CLIMB, 2020 1.92 [0.77; 4.80]
1.92 [0.77 ; 4.80 ] HER2CLIMB, 2020 1 0% 601 NA not evaluable 0.2 20.0 1.0 relative treatment effect www.metaEvidence.org 2024-09-30 21:00 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1;
studied treatment is better when TE < 1;
pathologies: 355,337,146,317
- treatments: 702,1313,498,1314,368,1301,1412,1298,1299,1334,1332,1303,1325,1320,1305,1300,1429,1324,1335,1307,1322,1319,718