Top evidence (RCT only, high risk of bias excluded)
Best available evidence (possibly low or very low)
All RCTs
All studies (RCT+OBS)
studies
metastatic/adv melanoma (mML), tremelimumab vs. chemotherapy, meta-analysis of study results Outcome TE 95% CI n k I2 ROB Pub. bias deaths (OS)detailed results A3671009, 2013 0.88 [0.75; 1.04]
0.88 [0.75 ; 1.04 ] A3671009, 2013 1 0% 655 NA not evaluable objective responses (ORR)detailed results A3671009, 2013 1.14 [0.69; 1.88]
1.14 [0.69 ; 1.88 ] A3671009, 2013 1 0% 655 NA not evaluable AE (any grade)detailed results A3671009, 2013 2.22 [1.12; 4.38]
2.22 [1.12 ; 4.38 ] A3671009, 2013 1 0% 644 NA not evaluable AE (grade 3-4)detailed results A3671009, 2013 1.84 [1.35; 2.52]
1.84 [1.35 ; 2.52 ] A3671009, 2013 1 0% 644 NA not evaluable AE leading to death (grade 5)detailed results A3671009, 2013 1.71 [0.85; 3.45]
1.71 [0.85 ; 3.45 ] A3671009, 2013 1 0% 644 NA not evaluable AE leading to treatment discontinuation (any grade)detailed results A3671009, 2013 97.13 [5.95; 1585.40]
97.13 [5.95 ; 1585.40 ] A3671009, 2013 1 0% 644 NA not evaluable SAE (any grade)detailed results A3671009, 2013 3.19 [2.19; 4.65]
3.19 [2.19 ; 4.65 ] A3671009, 2013 1 0% 644 NA not evaluable TRAE leading to death (grade 5)detailed results A3671009, 2013 7.00 [0.86; 57.23]
7.00 [0.86 ; 57.23 ] A3671009, 2013 1 0% 644 NA not evaluable Adrenal insufficiency TRAE (grade 3-4)detailed results A3671009, 2013 5.93 [0.30; 118.96]
5.93 [0.30 ; 118.96 ] A3671009, 2013 1 0% 644 NA not evaluable Eye disorders TRAE (grade 3-4)detailed results A3671009, 2013 0.98 [0.02; 49.62]
0.98 [0.02 ; 49.62 ] A3671009, 2013 1 0% 644 NA not evaluable Hepatitis TRAE (grade 3-4)detailed results A3671009, 2013 3.94 [0.18; 87.81]
3.94 [0.18 ; 87.81 ] A3671009, 2013 1 0% 644 NA not evaluable Pancreatitis TRAE (grade 3-4)detailed results A3671009, 2013 5.93 [0.30; 118.96]
5.93 [0.30 ; 118.96 ] A3671009, 2013 1 0% 644 NA not evaluable Abdominal pain AE (grade 3-4)detailed results A3671009, 2013 4.04 [1.13; 14.45]
4.04 [1.13 ; 14.45 ] A3671009, 2013 1 0% 644 NA not evaluable Asthenia AE (grade 3-4)detailed results A3671009, 2013 0.10 [0.01; 1.78]
0.10 [0.01 ; 1.78 ] A3671009, 2013 1 0% 644 NA not evaluable Constipation AE (grade 3-4)detailed results A3671009, 2013 0.98 [0.14; 7.01]
0.98 [0.14 ; 7.01 ] A3671009, 2013 1 0% 644 NA not evaluable Cough AE (grade 3-4)detailed results A3671009, 2013 1.97 [0.07; 58.81]
1.97 [0.07 ; 58.81 ] A3671009, 2013 1 0% 644 NA not evaluable Decreased appetite AE (grade 3-4)detailed results A3671009, 2013 14.32 [1.87; 109.52]
14.32 [1.87 ; 109.52 ] A3671009, 2013 1 0% 644 NA not evaluable Dyspnoea AE (grade 3-4)detailed results A3671009, 2013 4.00 [0.84; 18.98]
4.00 [0.84 ; 18.98 ] A3671009, 2013 1 0% 644 NA not evaluable Fatigue AE (grade 3-4)detailed results A3671009, 2013 3.90 [1.44; 10.57]
3.90 [1.44 ; 10.57 ] A3671009, 2013 1 0% 644 NA not evaluable Headache AE (grade 3-4)detailed results A3671009, 2013 1.97 [0.18; 21.82]
1.97 [0.18 ; 21.82 ] A3671009, 2013 1 0% 644 NA not evaluable Nausea AE (grade 3-4)detailed results A3671009, 2013 1.39 [0.61; 3.18]
1.39 [0.61 ; 3.18 ] A3671009, 2013 1 0% 644 NA not evaluable Neutropenia AE (grade 3-4)detailed results A3671009, 2013 0.03 [0.00; 0.19]
0.03 [0.00 ; 0.19 ] A3671009, 2013 1 0% 644 NA not evaluable Peripheral oedema AE (grade 3-4)detailed results A3671009, 2013 4.97 [0.58; 42.77]
4.97 [0.58 ; 42.77 ] A3671009, 2013 1 0% 644 NA not evaluable Pruritus AE (grade 3-4)detailed results A3671009, 2013 5.93 [0.30; 118.96]
5.93 [0.30 ; 118.96 ] A3671009, 2013 1 0% 644 NA not evaluable Pyrexia AE (grade 3-4)detailed results A3671009, 2013 7.94 [0.42; 150.76]
7.94 [0.42 ; 150.76 ] A3671009, 2013 1 0% 644 NA not evaluable Rash AE (grade 3-4)detailed results A3671009, 2013 7.00 [0.86; 57.23]
7.00 [0.86 ; 57.23 ] A3671009, 2013 1 0% 644 NA not evaluable Thrombocytopenia AE (grade 3-4)detailed results A3671009, 2013 0.03 [0.00; 0.26]
0.03 [0.00 ; 0.26 ] A3671009, 2013 1 0% 644 NA not evaluable Vomiting AE (grade 3-4)detailed results A3671009, 2013 1.55 [0.66; 3.64]
1.55 [0.66 ; 3.64 ] A3671009, 2013 1 0% 644 NA not evaluable Weight decreased AE (grade 3-4)detailed results A3671009, 2013 0.98 [0.06; 15.76]
0.98 [0.06 ; 15.76 ] A3671009, 2013 1 0% 644 NA not evaluable 0.0 200.0 1.0 relative treatment effect www.metaEvidence.org 2024-10-05 14:35 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1;
studied treatment is better when TE < 1;
pathologies: 283,284,70,235,285,68,127,128,286,69,129
- treatments: 556