All patients
Age < 65y (younger) Age > 75y (older) ECOG 0 ECOG 1 Gender, female Gender, male metastasis (brain) NO metastasis (brain) YES PD-L1 < 1% PD-L1 < 10% PD-L1 < 5% PD-L1 > 1% PD-L1 > 10% PD-L1 > 5% smoker (current or former) smoker (never)
Top evidence (RCT only, high risk of bias excluded)
Best available evidence (possibly low or very low)
All RCTs
All studies (RCT+OBS)
studies
non squamous cell - mNSCLC - L2, anti-PD-(L)1 vs. chemotherapy, meta-analysis of study results Outcome TE 95% CI n k I2 ROB Pub. bias deaths (OS)detailed results CheckMate 057, 2015 0.73 [0.59; 0.90]
0.73 [0.59 ; 0.90 ] CheckMate 057, 2015 1 0% 582 NA not evaluable progression or deaths (PFS)detailed results CheckMate 057, 2015 0.92 [0.77; 1.10]
0.92 [0.77 ; 1.10 ] CheckMate 057, 2015 1 0% 582 NA not evaluable objective responses (ORR)detailed results CheckMate 057, 2015 1.70 [1.11; 2.61]
1.70 [1.11 ; 2.61 ] CheckMate 057, 2015 1 0% 582 NA not evaluable AE (any grade)detailed results CheckMate 057, 2015 0.31 [0.20; 0.48]
0.31 [0.20 ; 0.48 ] CheckMate 057, 2015 1 0% 555 NA not evaluable AE (grade 3-4)detailed results CheckMate 057, 2015 0.42 [0.29; 0.59]
0.42 [0.29 ; 0.59 ] CheckMate 057, 2015 1 0% 555 NA not evaluable STRAE (any grade)detailed results CheckMate 057, 2015 0.32 [0.19; 0.55]
0.32 [0.19 ; 0.55 ] CheckMate 057, 2015 1 0% 555 NA not evaluable STRAE (grade 3-4)detailed results CheckMate 057, 2015 0.25 [0.14; 0.46]
0.25 [0.14 ; 0.46 ] CheckMate 057, 2015 1 0% 555 NA not evaluable TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.10 [0.06; 0.16]
0.10 [0.06 ; 0.16 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Acute kidney injury TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Alopecia TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Anaemia TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.13 [0.02; 1.07]
0.13 [0.02 ; 1.07 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Arthralgia TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Asthenia TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.15 [0.02; 1.28]
0.15 [0.02 ; 1.28 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Blood creatinine increased TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Colitis TRAE (grade 3-4)detailed results CheckMate 057, 2015 1.87 [0.06; 55.99]
1.87 [0.06 ; 55.99 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Constipation TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.23 [0.01; 5.17]
0.23 [0.01 ; 5.17 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Decreased appetite TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.15 [0.01; 3.09]
0.15 [0.01 ; 3.09 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Diabetes TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Diarrhoea TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.62 [0.10; 3.74]
0.62 [0.10 ; 3.74 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Dysgeusia TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Eczema TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Erythema TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Fatigue TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.21 [0.06; 0.74]
0.21 [0.06 ; 0.74 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Febrile neutropenia TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.02 [0.00; 0.27]
0.02 [0.00 ; 0.27 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Hypersensitivity TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Hyperthyroidism TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Hypothyroidism TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Increase AST TRAE (grade 3-4)detailed results CheckMate 057, 2015 1.87 [0.06; 55.99]
1.87 [0.06 ; 55.99 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Increased ALT TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.47 [0.02; 13.95]
0.47 [0.02 ; 13.95 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Increased lacrimation (TRAE grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Infusion-related reactions TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.47 [0.02; 13.95]
0.47 [0.02 ; 13.95 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Leucopenia TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.02 [0.00; 0.32]
0.02 [0.00 ; 0.32 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Maculopapular rash TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Mucosal inflammation TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.09 [0.00; 1.69]
0.09 [0.00 ; 1.69 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Myalgia TRAE (grade 3-4)detailed results CheckMate 057, 2015 1.87 [0.06; 55.99]
1.87 [0.06 ; 55.99 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Nausea TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.13; 6.67]
0.93 [0.13 ; 6.67 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Neutropenia TRAE (grade 3-4)detailed results Out of scale CheckMate 057, 2015 0.00 [0.00; 0.08]
0.00 [0.00 ; 0.08 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Palmar-plantar erythrodysaesthesia syndrome TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Paraesthesia TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Peripheral neuropathy TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.15 [0.01; 3.09]
0.15 [0.01 ; 3.09 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Peripheral oedema TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.47 [0.02; 13.95]
0.47 [0.02 ; 13.95 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Pneumonitis TRAE (grade 3-4)detailed results CheckMate 057, 2015 2.82 [0.29; 27.28]
2.82 [0.29 ; 27.28 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Pruritic rash TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Pruritus generalised TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Pruritus TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Pyrexia TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Rash TRAE (grade 3-4)detailed results CheckMate 057, 2015 1.87 [0.06; 55.99]
1.87 [0.06 ; 55.99 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Skin exfoliation TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Stomatitis TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.23 [0.01; 5.17]
0.23 [0.01 ; 5.17 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Thyroiditis TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Urticaria TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Vomiting TRAE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Abdominal pain AE (grade 3-4)detailed results CheckMate 057, 2015 0.15 [0.01; 3.09]
0.15 [0.01 ; 3.09 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Alopecia AE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Anaemia AE (grade 3-4)detailed results CheckMate 057, 2015 0.38 [0.13; 1.09]
0.38 [0.13 ; 1.09 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Arthralgia AE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.13; 6.67]
0.93 [0.13 ; 6.67 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Asthenia AE (grade 3-4)detailed results CheckMate 057, 2015 0.84 [0.35; 2.02]
0.84 [0.35 ; 2.02 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Back pain AE (grade 3-4)detailed results CheckMate 057, 2015 2.36 [0.45; 12.26]
2.36 [0.45 ; 12.26 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Constipation AE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.13; 6.67]
0.93 [0.13 ; 6.67 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Cough AE (grade 3-4)detailed results CheckMate 057, 2015 1.87 [0.06; 55.99]
1.87 [0.06 ; 55.99 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Decreased appetite AE (grade 3-4)detailed results CheckMate 057, 2015 1.17 [0.31; 4.40]
1.17 [0.31 ; 4.40 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Diarrhoea AE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.19; 4.66]
0.93 [0.19 ; 4.66 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Dizziness AE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.06; 15.00]
0.93 [0.06 ; 15.00 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Dry skin AE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Dysgeusia AE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Dyspnoea AE (grade 3-4)detailed results CheckMate 057, 2015 1.32 [0.58; 3.03]
1.32 [0.58 ; 3.03 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Erythema AE (grade 3-4)detailed results CheckMate 057, 2015 0.47 [0.02; 13.95]
0.47 [0.02 ; 13.95 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Fatigue AE (grade 3-4)detailed results CheckMate 057, 2015 0.45 [0.20; 1.02]
0.45 [0.20 ; 1.02 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Febrile neutropenia AE (grade 3-4)detailed results CheckMate 057, 2015 0.01 [0.00; 0.24]
0.01 [0.00 ; 0.24 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Headache AE (grade 3-4)detailed results CheckMate 057, 2015 3.75 [0.17; 83.63]
3.75 [0.17 ; 83.63 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Hypothyroidism AE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Increased ALT AE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.06; 15.00]
0.93 [0.06 ; 15.00 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Lacrimation increased AE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Leucopenia AE (grade 3-4)detailed results CheckMate 057, 2015 0.02 [0.00; 0.31]
0.02 [0.00 ; 0.31 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Mucosal inflammation AE (grade 3-4)detailed results CheckMate 057, 2015 0.18 [0.02; 1.58]
0.18 [0.02 ; 1.58 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Myalgia AE (grade 3-4)detailed results CheckMate 057, 2015 1.87 [0.06; 55.99]
1.87 [0.06 ; 55.99 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Nausea AE (grade 3-4)detailed results CheckMate 057, 2015 2.36 [0.45; 12.26]
2.36 [0.45 ; 12.26 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Neutropenia AE (grade 3-4)detailed results Out of scale CheckMate 057, 2015 0.01 [0.00; 0.07]
0.01 [0.00 ; 0.07 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Oropharyngeal pain AE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Paraesthesia AE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Peripheral neuropathy AE (grade 3-4)detailed results CheckMate 057, 2015 0.15 [0.01; 3.09]
0.15 [0.01 ; 3.09 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Peripheral oedema AE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.13; 6.67]
0.93 [0.13 ; 6.67 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Pneumonia AE (grade 3-4)detailed results CheckMate 057, 2015 0.65 [0.29; 1.50]
0.65 [0.29 ; 1.50 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Pruritus AE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Pyrexia AE (grade 3-4)detailed results CheckMate 057, 2015 1.87 [0.06; 55.99]
1.87 [0.06 ; 55.99 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Rash AE (grade 3-4)detailed results CheckMate 057, 2015 1.87 [0.06; 55.99]
1.87 [0.06 ; 55.99 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Stomatitis AE (grade 3-4)detailed results CheckMate 057, 2015 0.47 [0.04; 5.16]
0.47 [0.04 ; 5.16 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Vomiting AE (grade 3-4)detailed results CheckMate 057, 2015 1.87 [0.06; 55.99]
1.87 [0.06 ; 55.99 ] CheckMate 057, 2015 1 0% 555 NA not evaluable Weight decreased AE (grade 3-4)detailed results CheckMate 057, 2015 0.93 [0.02; 47.22]
0.93 [0.02 ; 47.22 ] CheckMate 057, 2015 1 0% 555 NA not evaluable 0.0 5.0 1.0 relative treatment effect www.metaEvidence.org 2024-10-05 01:10 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1;
studied treatment is better when TE < 1;
pathologies: 279,167,1,170,261
- treatments: 367,851,361,602,1070,671,865,744,696,1083,1281,1282,1283,1082,866,852,417,603,1051,876,853,1018,661,673,1049,1440,1561,854,374,953,672,1080,1560,1073,862,1562,1565,855,360,719,721,720,842,642,674,1085,863,503,847,982,359,575,577,576,869,1081,981,875,505,952,1021,1079,767,1071,1074,873,561,644,1251,1044,724,874,1043,1041,1042,940,1258,1563