studies

metastatic/advanced - colorectal cancer (mCRC), immune chekpoint inhibitors vs. ..., meta-analysis of study results

OutcomeTE95% CInkI2ROBPub. bias deaths (OS)detailed resultsAtezoTRIBE, 2022 0.66 [0.36; 1.19] 0.66[0.36; 1.19]AtezoTRIBE, 202210%218NAnot evaluable progression or deaths (PFS)detailed resultsAtezoTRIBE, 2022 0.70 [0.57; 0.86] 0.70[0.57; 0.86]AtezoTRIBE, 202210%218NAnot evaluable objective responses (ORR)detailed resultsAtezoTRIBE, 2022 0.78 [0.53; 1.14] 0.78[0.53; 1.14]AtezoTRIBE, 202210%218NAnot evaluable objective responses (ORR) (extension)detailed resultsAtezoTRIBE, 2022 0.77 [0.44; 1.36] 0.77[0.44; 1.36]AtezoTRIBE, 202210%218NAnot evaluable AE (grade 3-4)detailed resultsAtezoTRIBE, 2022 1.29 [0.71; 2.32] 1.29[0.71; 2.32]AtezoTRIBE, 202210%214NAnot evaluable AE leading to death (grade 5)detailed resultsAtezoTRIBE, 2022 2.03 [0.09; 45.56] 2.03[0.09; 45.56]AtezoTRIBE, 202210%218NAnot evaluable AE leading to treatment discontinuation (any grade)detailed resultsAtezoTRIBE, 2022 3.09 [0.15; 62.46] 3.09[0.15; 62.46]AtezoTRIBE, 202210%214NAnot evaluable SAE (any grade)detailed resultsAtezoTRIBE, 2022 1.06 [0.56; 2.00] 1.06[0.56; 2.00]AtezoTRIBE, 202210%214NAnot evaluable0.55.01.0relative treatment effectwww.metaEvidence.org2024-10-02 14:02 +02:00

TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers); k: number of studies; n: total number of patients; ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1; studied treatment is better when TE < 1;

pathologies: 183,384,137,138 - treatments: 204,504,850,329,558,579,549,868,502,741,556,812,813,367,851,361,602,1070,671,865,744,696,1083,1281,1282,1283,1082,866,852,417,603,1051,876,853,1018,661,673,1049,1440,1561,854,374,953,672,1080,1560,1073,862,1562,1565,855,360,719,721,720,842,642,674,1085,863,503,847,982,359,575,577,576,869,1081,981,875,505,952,1021,1079,767,1071,1074,873,561,644,1251,1044,724,874,1043,1041,1042,940,1258,1563,746,745,856,634,861,416,864,769,980,369,743