All patients
Age < 65y (younger) Age > 65y Age > 75y (older) Asian type BRAF mutant BRAF wild type dMMR ECOG 0 ECOG 1 Gender, female Gender, male PD-L1 < 1% PD-L1 > 1% RAS mutant RAS wild type
Top evidence (RCT only, high risk of bias excluded)
Best available evidence (possibly low or very low)
All RCTs
All studies (RCT+OBS)
studies
colorectal cancer (CRC), anti-PD-(L)1 vs. ..., meta-analysis of study results Outcome TE 95% CI n k I2 ROB Pub. bias deaths (OS)detailed results AtezoTRIBE, 2022 0.66 [0.36; 1.19]
0.66 [0.36 ; 1.19 ] AtezoTRIBE, 2022 1 0% 218 NA not evaluable progression or deaths (PFS)detailed results AtezoTRIBE, 2022 0.70 [0.57; 0.86]
0.70 [0.57 ; 0.86 ] AtezoTRIBE, 2022 1 0% 218 NA not evaluable objective responses (ORR)detailed results AtezoTRIBE, 2022 0.78 [0.53; 1.14]
0.78 [0.53 ; 1.14 ] AtezoTRIBE, 2022 1 0% 218 NA not evaluable objective responses (ORR) (extension)detailed results AtezoTRIBE, 2022 0.77 [0.44; 1.36]
0.77 [0.44 ; 1.36 ] AtezoTRIBE, 2022 1 0% 218 NA not evaluable AE (grade 3-4)detailed results AtezoTRIBE, 2022 1.29 [0.71; 2.32]
1.29 [0.71 ; 2.32 ] AtezoTRIBE, 2022 1 0% 214 NA not evaluable AE leading to death (grade 5)detailed results AtezoTRIBE, 2022 2.03 [0.09; 45.56]
2.03 [0.09 ; 45.56 ] AtezoTRIBE, 2022 1 0% 218 NA not evaluable AE leading to treatment discontinuation (any grade)detailed results AtezoTRIBE, 2022 3.09 [0.15; 62.46]
3.09 [0.15 ; 62.46 ] AtezoTRIBE, 2022 1 0% 214 NA not evaluable SAE (any grade)detailed results AtezoTRIBE, 2022 1.06 [0.56; 2.00]
1.06 [0.56 ; 2.00 ] AtezoTRIBE, 2022 1 0% 214 NA not evaluable 0.5 5.0 1.0 relative treatment effect www.metaEvidence.org 2024-10-06 09:10 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1;
studied treatment is better when TE < 1;
pathologies: 126,385,183,384,137,138
- treatments: 367,851,361,602,1070,671,865,744,696,1083,1281,1282,1283,1082,866,852,417,603,1051,876,853,1018,661,673,1049,1440,1561,854,374,953,672,1080,1560,1073,862,1562,1565,855,360,719,721,720,842,642,674,1085,863,503,847,982,359,575,577,576,869,1081,981,875,505,952,1021,1079,767,1071,1074,873,561,644,1251,1044,724,874,1043,1041,1042,940,1258,1563