studies

mesothelioma (MS), immune chekpoint inhibitors vs. all, meta-analysis of study results

OutcomeTE95% CInkI2ROBPub. bias deaths (OS)detailed resultsCheckMate 743, 2021 0.74 [0.60; 0.91] DETERMINE, 2017 0.92 [0.76; 1.12] 0.83[0.67; 1.02]CheckMate 743, 2021, DETERMINE, 2017256%571lownot evaluable progression or deaths (PFS)detailed resultsCheckMate 743, 2021 1.00 [0.82; 1.21] DETERMINE, 2017 0.81 [0.67; 0.97] 0.90[0.73; 1.10]CheckMate 743, 2021, DETERMINE, 2017258%1,176lownot evaluable DCRdetailed resultsCheckMate 743, 2021 0.57 [0.38; 0.87] DETERMINE, 2017 1.39 [0.92; 2.09] 0.89[0.37; 2.12]CheckMate 743, 2021, DETERMINE, 2017289%1,176lownot evaluable objective responses (ORR)detailed resultsCheckMate 743, 2021 0.88 [0.64; 1.22] DETERMINE, 2017 4.35 [1.00; 19.05] 1.65[0.36; 7.65]CheckMate 743, 2021, DETERMINE, 2017277%1,176moderatenot evaluable STRAE (any grade)detailed resultsCheckMate 743, 2021 0.92 [0.65; 1.31] 0.92[0.65; 1.31]CheckMate 743, 202110%584NAnot evaluable TRAE (grade 3-4)detailed resultsDETERMINE, 2017 1.74 [1.22; 2.47] 1.74[1.22; 2.47]DETERMINE, 201710%569NAnot evaluable TRAE leading to death (grade 5)detailed resultsCheckMate 743, 2021 2.86 [0.30; 27.64] DETERMINE, 2017 1.50 [0.76; 2.95] 1.58[0.82; 3.03]CheckMate 743, 2021, DETERMINE, 201720%1,153lownot evaluable TRAE leading to discontinuation (any grade)detailed resultsCheckMate 743, 2021 1.59 [1.05; 2.41] 1.59[1.05; 2.41]CheckMate 743, 202110%584NAnot evaluable TRAE leading to discontinuation (grade 3-4)detailed resultsCheckMate 743, 2021 2.21 [1.28; 3.81] 2.21[1.28; 3.81]CheckMate 743, 202110%584NAnot evaluable Abdominal pain TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 0.47 [0.02; 14.14] DETERMINE, 2017 0.57 [0.19; 1.73] 0.56[0.20; 1.61]CheckMate 743, 2021, DETERMINE, 201720%1,153lownot evaluable Acute kidney injury TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 7.66 [0.40; 145.59] DETERMINE, 2017 3.00 [0.15; 60.20] 4.84[0.59; 39.53]CheckMate 743, 2021, DETERMINE, 201720%1,153moderatenot evaluable Adrenal insufficiency TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 1.90 [0.06; 56.75] DETERMINE, 2017 0.99 [0.03; 29.79] 1.37[0.12; 15.19]CheckMate 743, 2021, DETERMINE, 201720%1,153moderatenot evaluable Anaemia TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 0.03 [0.00; 0.19] DETERMINE, 2017 1.68 [0.46; 6.16] 0.23[0.00; 13.19]CheckMate 743, 2021, DETERMINE, 2017291%1,153lownot evaluable Arthralgia TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 1.90 [0.06; 56.75] DETERMINE, 2017 0.99 [0.03; 29.79] 1.37[0.12; 15.19]CheckMate 743, 2021, DETERMINE, 201720%1,153moderatenot evaluable Arthritis TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 3.81 [0.17; 84.75] DETERMINE, 2017 0.99 [0.03; 29.79] 2.07[0.21; 20.46]CheckMate 743, 2021, DETERMINE, 201720%1,153moderatenot evaluable Asthenia TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 0.04 [0.00; 0.64] DETERMINE, 2017 1.50 [0.40; 5.62] 0.30[0.01; 10.72]CheckMate 743, 2021, DETERMINE, 2017281%1,153lownot evaluable Back pain (TRAE grade 3-4)detailed resultsDETERMINE, 2017 0.08 [0.00; 1.64] 0.08[0.00; 1.64]DETERMINE, 201710%569NAnot evaluable Chills TRAE (grade 3-4)detailed resultsDETERMINE, 2017 0.99 [0.03; 29.79] 0.99[0.03; 29.79]DETERMINE, 201710%569NAnot evaluable Colitis TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 6.76 [0.83; 55.31] DETERMINE, 2017 25.42 [1.54; 420.53] 10.88[2.02; 58.51]CheckMate 743, 2021, DETERMINE, 201720%1,153moderatenot evaluable Constipation TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 0.47 [0.02; 14.14] DETERMINE, 2017 0.25 [0.02; 2.74] 0.31[0.04; 2.19]CheckMate 743, 2021, DETERMINE, 201720%1,153lownot evaluable Cough TRAE (grade 3-4)detailed resultsDETERMINE, 2017 0.25 [0.01; 7.42] 0.25[0.01; 7.42]DETERMINE, 201710%569NAnot evaluable Decreased appetite TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 0.95 [0.13; 6.76] DETERMINE, 2017 2.01 [0.42; 9.56] 1.50[0.44; 5.10]CheckMate 743, 2021, DETERMINE, 201720%1,153lownot evaluable Dermatitis acneiform TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 1.90 [0.06; 56.75] 1.90[0.06; 56.75]CheckMate 743, 202110%584NAnot evaluable Diarrhoea TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 4.86 [1.06; 22.39] DETERMINE, 2017 33.86 [4.65; 246.49] 11.52[1.74; 76.27]CheckMate 743, 2021, DETERMINE, 2017257%1,153moderatenot evaluable Dyspepsia TRAE (grade 3-4)detailed resultsDETERMINE, 2017 0.25 [0.01; 7.42] 0.25[0.01; 7.42]DETERMINE, 201710%569NAnot evaluable Dyspnoea TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 0.47 [0.02; 14.14] DETERMINE, 2017 0.58 [0.33; 1.02] 0.58[0.33; 1.01]CheckMate 743, 2021, DETERMINE, 201720%1,153lownot evaluable Epistaxis TRAE (grade 3-4)detailed resultsDETERMINE, 2017 0.99 [0.03; 29.79] 0.99[0.03; 29.79]DETERMINE, 201710%569NAnot evaluable Fatigue TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 0.56 [0.13; 2.38] DETERMINE, 2017 0.49 [0.14; 1.72] 0.52[0.20; 1.34]CheckMate 743, 2021, DETERMINE, 201720%1,153lownot evaluable Febrile neutropenia TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 0.16 [0.01; 3.14] 0.16[0.01; 3.14]CheckMate 743, 202110%584NAnot evaluable Guillain-Barré syndrome TRAE (grade 3-4)detailed resultsDETERMINE, 2017 0.99 [0.03; 29.79] 0.99[0.03; 29.79]DETERMINE, 201710%569NAnot evaluable Hepatitis TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 3.81 [0.17; 84.75] DETERMINE, 2017 0.99 [0.03; 29.79] 2.07[0.21; 20.46]CheckMate 743, 2021, DETERMINE, 201720%1,153moderatenot evaluable Hypersensitivity TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 1.90 [0.06; 56.75] 1.90[0.06; 56.75]CheckMate 743, 202110%584NAnot evaluable Hypophysitis TRAE (grade 3-4)detailed resultsDETERMINE, 2017 3.00 [0.15; 60.20] 3.00[0.15; 60.20]DETERMINE, 201710%569NAnot evaluable Hypothyroidism TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 0.95 [0.02; 47.87] DETERMINE, 2017 0.99 [0.03; 29.79] 0.97[0.07; 12.71]CheckMate 743, 2021, DETERMINE, 201720%1,153lownot evaluable Increase AST TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 5.73 [0.29; 114.85] 5.73[0.29; 114.85]CheckMate 743, 202110%584NAnot evaluable Increased ALT TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 9.61 [0.52; 176.72] DETERMINE, 2017 1.75 [0.36; 8.53] 2.60[0.64; 10.59]CheckMate 743, 2021, DETERMINE, 201721%1,153lownot evaluable Increased lipase level TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 11.79 [1.52; 91.29] DETERMINE, 2017 1.85 [0.51; 6.71] 3.91[0.66; 23.24]CheckMate 743, 2021, DETERMINE, 2017256%1,153lownot evaluable Infusion-related reactions TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 5.73 [0.29; 114.85] DETERMINE, 2017 0.99 [0.03; 29.79] 2.66[0.28; 25.23]CheckMate 743, 2021, DETERMINE, 201720%1,153moderatenot evaluable Maculopapular rash TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 1.90 [0.06; 56.75] 1.90[0.06; 56.75]CheckMate 743, 202110%584NAnot evaluable Mucosal inflammation TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 0.24 [0.01; 5.24] 0.24[0.01; 5.24]CheckMate 743, 202110%584NAnot evaluable Myalgia TRAE (grade 3-4)detailed resultsDETERMINE, 2017 1.99 [0.09; 44.45] 1.99[0.09; 44.45]DETERMINE, 201710%569NAnot evaluable Myocarditis TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 1.90 [0.06; 56.75] 1.90[0.06; 56.75]CheckMate 743, 202110%584NAnot evaluable Myositis TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 3.81 [0.17; 84.75] 3.81[0.17; 84.75]CheckMate 743, 202110%584NAnot evaluable Nausea TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 0.13 [0.02; 1.08] DETERMINE, 2017 2.00 [0.22; 18.02] 0.50[0.04; 7.22]CheckMate 743, 2021, DETERMINE, 2017267%1,153moderatenot evaluable Neutropenia TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 0.04 [0.01; 0.16] DETERMINE, 2017 0.99 [0.18; 5.48] 0.19[0.01; 4.62]CheckMate 743, 2021, DETERMINE, 2017288%1,153moderatenot evaluable Pancreatitis TRAE (grade 3-4)detailed resultsDETERMINE, 2017 0.99 [0.03; 29.79] 0.99[0.03; 29.79]DETERMINE, 201710%569NAnot evaluable Pancytopenia TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 0.09 [0.01; 1.71] DETERMINE, 2017 0.25 [0.01; 7.42] 0.14[0.02; 1.29]CheckMate 743, 2021, DETERMINE, 201720%1,153moderatenot evaluable Paraesthesia TRAE (grade 3-4)detailed resultsDETERMINE, 2017 0.99 [0.03; 29.79] 0.99[0.03; 29.79]DETERMINE, 201710%569NAnot evaluable Peripheral oedema TRAE (grade 3-4)detailed resultsDETERMINE, 2017 1.99 [0.09; 44.45] 1.99[0.09; 44.45]DETERMINE, 201710%569NAnot evaluable Pneumonia TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 0.47 [0.02; 14.14] DETERMINE, 2017 0.89 [0.29; 2.70] 0.84[0.29; 2.41]CheckMate 743, 2021, DETERMINE, 201720%1,153lownot evaluable Pneumonitis TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 1.90 [0.06; 56.75] DETERMINE, 2017 0.99 [0.03; 29.79] 1.37[0.12; 15.19]CheckMate 743, 2021, DETERMINE, 201720%1,153moderatenot evaluable Pruritus TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 5.73 [0.29; 114.85] DETERMINE, 2017 3.00 [0.15; 60.20] 4.15[0.50; 34.55]CheckMate 743, 2021, DETERMINE, 201720%1,153moderatenot evaluable Pyrexia TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 0.47 [0.02; 14.14] DETERMINE, 2017 3.00 [0.15; 60.20] 1.34[0.14; 12.66]CheckMate 743, 2021, DETERMINE, 201720%1,153lownot evaluable Rash TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 5.73 [0.29; 114.85] DETERMINE, 2017 1.99 [0.09; 44.45] 3.44[0.40; 29.74]CheckMate 743, 2021, DETERMINE, 201720%1,153moderatenot evaluable Sepsis TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 0.47 [0.02; 14.14] DETERMINE, 2017 3.02 [0.36; 25.23] 1.79[0.30; 10.85]CheckMate 743, 2021, DETERMINE, 201720%1,153lownot evaluable Stomatitis TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 0.47 [0.02; 14.14] DETERMINE, 2017 0.99 [0.03; 29.79] 0.69[0.06; 7.58]CheckMate 743, 2021, DETERMINE, 201720%1,153moderatenot evaluable Thrombocytopenia TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 0.18 [0.04; 0.85] DETERMINE, 2017 1.50 [0.15; 14.48] 0.44[0.06; 3.34]CheckMate 743, 2021, DETERMINE, 2017256%1,153moderatenot evaluable Vomiting TRAE (grade 3-4)detailed resultsCheckMate 743, 2021 0.08 [0.00; 1.39] DETERMINE, 2017 0.87 [0.25; 3.00] 0.37[0.04; 3.57]CheckMate 743, 2021, DETERMINE, 2017256%1,153lownot evaluable Weight decreased TRAE (grade 3-4)detailed resultsDETERMINE, 2017 0.99 [0.09; 11.04] 0.99[0.09; 11.04]DETERMINE, 201710%569NAnot evaluable0.020.01.0relative treatment effectwww.metaEvidence.org2024-07-07 00:43 +02:00

TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers); k: number of studies; n: total number of patients; ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1; studied treatment is better when TE < 1;

pathologies: 139,222,223,221 - treatments: 204,504,850,329,558,579,549,868,502,741,556,812,813,367,851,361,602,1070,671,865,744,696,1083,1281,1282,1283,1082,866,852,417,603,1051,876,853,1018,661,673,1049,1440,854,374,1073,953,672,1080,862,855,360,719,721,720,842,642,674,1085,863,503,847,982,359,575,577,576,869,1081,981,875,505,952,1021,1079,767,1071,1074,873,561,644,1251,1044,724,874,1043,1041,1042,940,1258,746,745,856,634,861,416,864,769,980,369,743