Top evidence (RCT only, high risk of bias excluded)
Best available evidence (possibly low or very low)
All RCTs
All studies (RCT+OBS)
non squamous cell - mNSCLC - L2, ... vs. all, meta-analysis of study results Outcome TE 95% CI n k I2 ROB Pub. bias deaths (OS)detailed results LUX-LUNG 8, 2015 (REV) 1.23 [1.05; 1.45]
1.23 [1.05 ; 1.45 ] LUX-LUNG 8, 2015 (REV) 1 0% 795 NA not evaluable progression or deaths (PFS)detailed results LUX-LUNG 8, 2015 (REV) 1.23 [1.05; 1.46]
1.23 [1.05 ; 1.46 ] LUX-LUNG 8, 2015 (REV) 1 0% 795 NA not evaluable DCRdetailed results LUX-LUNG 8, 2015 (REV) 0.64 [0.48; 0.85]
0.64 [0.48 ; 0.85 ] LUX-LUNG 8, 2015 (REV) 1 0% 795 NA not evaluable objective responses (ORR)detailed results LUX-LUNG 8, 2015 (REV) 0.49 [0.23; 1.02]
0.49 [0.23 ; 1.02 ] LUX-LUNG 8, 2015 (REV) 1 0% 795 NA not evaluable AE (any grade)detailed results LUX-LUNG 8, 2015 (REV) 0.20 [0.04; 0.91]
0.20 [0.04 ; 0.91 ] LUX-LUNG 8, 2015 (REV) 1 0% 787 NA not evaluable AE (grade 3-4)detailed results LUX-LUNG 8, 2015 (REV) 1.02 [0.77; 1.36]
1.02 [0.77 ; 1.36 ] LUX-LUNG 8, 2015 (REV) 1 0% 787 NA not evaluable SAE (any grade)detailed results LUX-LUNG 8, 2015 (REV) 1.00 [0.75; 1.32]
1.00 [0.75 ; 1.32 ] LUX-LUNG 8, 2015 (REV) 1 0% 787 NA not evaluable STRAE (any grade)detailed results LUX-LUNG 8, 2015 (REV) 0.43 [0.26; 0.73]
0.43 [0.26 ; 0.73 ] LUX-LUNG 8, 2015 (REV) 1 0% 787 NA not evaluable TRAE (any grade)detailed results LUX-LUNG 8, 2015 (REV) 0.31 [0.19; 0.49]
0.31 [0.19 ; 0.49 ] LUX-LUNG 8, 2015 (REV) 1 0% 787 NA not evaluable TRAE (grade 3-4)detailed results LUX-LUNG 8, 2015 (REV) 0.56 [0.40; 0.80]
0.56 [0.40 ; 0.80 ] LUX-LUNG 8, 2015 (REV) 1 0% 795 NA not evaluable TRAE leading to death (grade 5)detailed results LUX-LUNG 8, 2015 (REV) 0.82 [0.25; 2.73]
0.82 [0.25 ; 2.73 ] LUX-LUNG 8, 2015 (REV) 1 0% 787 NA not evaluable TRAE leading to discontinuation (any grade)detailed results LUX-LUNG 8, 2015 (REV) 0.81 [0.56; 1.16]
0.81 [0.56 ; 1.16 ] LUX-LUNG 8, 2015 (REV) 1 0% 787 NA not evaluable 0.0 2.0 1.0 relative treatment effect www.metaEvidence.org 2024-07-09 01:27 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
pathologies: 279,167,1,170,261
- treatments: 430
