All patients
Age < 65y (younger) Age > 65y Asian type ECOG 0 ECOG 1 Gender, female Gender, male P16 negative (HPV) P16 positive (HPV) PDL1 < 25% PDL1 >25%
Top evidence (RCT only, high risk of bias excluded)
Best available evidence (possibly low or very low)
All RCTs
All studies (RCT+OBS)
studies
locally advanced (laHNSCC), immune chekpoint inhibitors vs. all, meta-analysis of study results Outcome TE 95% CI n k I2 ROB Pub. bias deaths (OS)detailed results JAVELIN Head and Neck 100, 2021 1.31 [0.93; 1.85]
1.31 [0.93 ; 1.85 ] JAVELIN Head and Neck 100, 2021 1 0% 697 NA not evaluable progression or deaths (PFS)detailed results JAVELIN Head and Neck 100, 2021 1.21 [0.93; 1.57]
1.21 [0.93 ; 1.57 ] JAVELIN Head and Neck 100, 2021 1 0% 697 NA not evaluable objective responses (ORR)detailed results JAVELIN Head and Neck 100, 2021 0.95 [0.66; 1.36]
0.95 [0.66 ; 1.36 ] JAVELIN Head and Neck 100, 2021 1 0% 697 NA not evaluable AE (any grade)detailed results JAVELIN Head and Neck 100, 2021 0.67 [0.11; 4.05]
0.67 [0.11 ; 4.05 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable AE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.54 [1.02; 2.33]
1.54 [1.02 ; 2.33 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable STRAE (any grade)detailed results JAVELIN Head and Neck 100, 2021 1.19 [0.87; 1.64]
1.19 [0.87 ; 1.64 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable TRAE (any grade)detailed results JAVELIN Head and Neck 100, 2021 0.67 [0.19; 2.40]
0.67 [0.19 ; 2.40 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.38 [0.97; 1.97]
1.38 [0.97 ; 1.97 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable TRAE leading to death (grade 5)detailed results JAVELIN Head and Neck 100, 2021 1.98 [0.18; 21.97]
1.98 [0.18 ; 21.97 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Abdominal pain TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.49 [0.02; 14.76]
0.49 [0.02 ; 14.76 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Acute kidney injury TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.24 [0.48; 3.19]
1.24 [0.48 ; 3.19 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Adrenal insufficiency TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.49 [0.02; 14.76]
0.49 [0.02 ; 14.76 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Anaemia TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.91 [0.58; 1.43]
0.91 [0.58 ; 1.43 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Asthenia TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.50 [0.61; 3.72]
1.50 [0.61 ; 3.72 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Blood creatinine increased TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.39 [0.44; 4.43]
1.39 [0.44 ; 4.43 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Chills TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.98 [0.07; 59.21]
1.98 [0.07 ; 59.21 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Colitis TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.25 [0.01; 5.48]
0.25 [0.01 ; 5.48 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Constipation TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.98 [0.07; 59.21]
1.98 [0.07 ; 59.21 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Cough TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.98 [0.07; 59.21]
1.98 [0.07 ; 59.21 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Decreased appetite TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.36 [0.71; 2.60]
1.36 [0.71 ; 2.60 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Diarrhoea TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.99 [0.14; 7.06]
0.99 [0.14 ; 7.06 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Dysgeusia TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.25 [0.01; 5.48]
0.25 [0.01 ; 5.48 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Dysphonia TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.99 [0.02; 49.96]
0.99 [0.02 ; 49.96 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Fatigue TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.16 [0.53; 2.54]
1.16 [0.53 ; 2.54 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Febrile neutropenia TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.76 [0.28; 2.08]
0.76 [0.28 ; 2.08 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Headache TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.98 [0.07; 59.21]
1.98 [0.07 ; 59.21 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Hypertension TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.99 [0.36; 10.93]
1.99 [0.36 ; 10.93 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Hyperthyroidism TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.98 [0.18; 21.97]
1.98 [0.18 ; 21.97 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Hypothyroidism TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.99 [0.02; 49.96]
0.99 [0.02 ; 49.96 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Increase AST TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.98 [0.18; 21.97]
1.98 [0.18 ; 21.97 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Increased ALT TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 7.04 [0.86; 57.54]
7.04 [0.86 ; 57.54 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Increased lipase level TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 5.00 [0.58; 43.02]
5.00 [0.58 ; 43.02 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Infusion-related reactions TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 3.97 [0.18; 88.38]
3.97 [0.18 ; 88.38 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Leucopenia TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.04 [0.55; 1.96]
1.04 [0.55 ; 1.96 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Mucosal inflammation TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.11 [0.72; 1.72]
1.11 [0.72 ; 1.72 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Nausea TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.30 [0.68; 2.49]
1.30 [0.68 ; 2.49 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Nephritis TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.98 [0.07; 59.21]
1.98 [0.07 ; 59.21 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Neutropenia TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.10 [0.73; 1.66]
1.10 [0.73 ; 1.66 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Pancytopenia TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.98 [0.07; 59.21]
1.98 [0.07 ; 59.21 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Peripheral neuropathy TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.25 [0.01; 5.48]
0.25 [0.01 ; 5.48 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Peripheral oedema TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.49 [0.02; 14.76]
0.49 [0.02 ; 14.76 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Pneumonia TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.76 [0.28; 2.08]
0.76 [0.28 ; 2.08 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Pneumonitis TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 10.01 [0.55; 184.02]
10.01 [0.55 ; 184.02 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Pyrexia TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.49 [0.04; 5.46]
0.49 [0.04 ; 5.46 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Rash TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.98 [0.07; 59.21]
1.98 [0.07 ; 59.21 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Sepsis TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.49 [0.04; 5.46]
0.49 [0.04 ; 5.46 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Stomatitis TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.99 [0.56; 1.74]
0.99 [0.56 ; 1.74 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Thrombocytopenia TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 9.31 [3.63; 23.82]
9.31 [3.63 ; 23.82 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Urticaria TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 1.98 [0.07; 59.21]
1.98 [0.07 ; 59.21 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Vomiting TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.88 [0.46; 1.70]
0.88 [0.46 ; 1.70 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable Weight decreased TRAE (grade 3-4)detailed results JAVELIN Head and Neck 100, 2021 0.66 [0.34; 1.29]
0.66 [0.34 ; 1.29 ] JAVELIN Head and Neck 100, 2021 1 0% 692 NA not evaluable 0.0 20.0 1.0 relative treatment effect www.metaEvidence.org 2024-10-05 08:36 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1;
studied treatment is better when TE < 1;
pathologies: 275,106,104,105
- treatments: 204,504,850,329,558,579,549,868,502,741,556,812,813,367,851,361,602,1070,671,865,744,696,1083,1281,1282,1283,1082,866,852,417,603,1051,876,853,1018,661,673,1049,1440,1561,854,374,953,672,1080,1560,1073,862,1562,1565,855,360,719,721,720,842,642,674,1085,863,503,847,982,359,575,577,576,869,1081,981,875,505,952,1021,1079,767,1071,1074,873,561,644,1251,1044,724,874,1043,1041,1042,940,1258,1563,746,745,856,634,861,416,864,769,980,369,743