Top evidence (RCT only, high risk of bias excluded)
Best available evidence (possibly low or very low)
All RCTs
All studies (RCT+OBS)
studies
mUC - M - PDL1 positive, immune chekpoint inhibitors vs. all, meta-analysis of study results Outcome TE 95% CI n k I2 ROB Pub. bias deaths (OS)detailed results JAVELIN Bladder 100 (PDL1>25%), 2020 0.56 [0.40; 0.79]
0.56 [0.40 ; 0.79 ] JAVELIN Bladder 100 (PDL1>25%), 2020 1 0% 358 NA not evaluable deaths (OS) (extension)detailed results JAVELIN Bladder 100 (PDL1>25%), 2020 0.69 [0.52; 0.91]
0.69 [0.52 ; 0.91 ] JAVELIN Bladder 100 (PDL1>25%), 2020 1 0% 358 NA not evaluable PFS (extension)detailed results JAVELIN Bladder 100 (PDL1>25%), 2020 0.46 [0.36; 0.59]
0.46 [0.36 ; 0.59 ] JAVELIN Bladder 100 (PDL1>25%), 2020 1 0% 358 NA not evaluable progression or deaths (PFS)detailed results JAVELIN Bladder 100 (PDL1>25%), 2020 0.56 [0.43; 0.73]
0.56 [0.43 ; 0.73 ] JAVELIN Bladder 100 (PDL1>25%), 2020 1 0% 358 NA not evaluable DCRdetailed results JAVELIN Bladder 100 (PDL1>25%), 2020 2.03 [1.31; 3.16]
2.03 [1.31 ; 3.16 ] JAVELIN Bladder 100 (PDL1>25%), 2020 1 0% 358 NA not evaluable objective responses (ORR)detailed results JAVELIN Bladder 100 (PDL1>25%), 2020 12.70 [2.11; 76.32]
12.70 [2.11 ; 76.32 ] JAVELIN Bladder 100 (PDL1>25%), 2020 1 0% 358 NA not evaluable 0.2 20.0 1.0 relative treatment effect www.metaEvidence.org 2024-09-27 23:15 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
studied treatment is better when TE > 1;
studied treatment is better when TE < 1;
pathologies: 189
- treatments: 204,504,850,329,558,579,549,868,502,741,556,812,813,367,851,361,602,1070,671,865,744,696,1083,1281,1282,1283,1082,866,852,417,603,1051,876,853,1018,661,673,1049,1440,1561,854,374,953,672,1080,1560,1073,862,1562,1565,855,360,719,721,720,842,642,674,1085,863,503,847,982,359,575,577,576,869,1081,981,875,505,952,1021,1079,767,1071,1074,873,561,644,1251,1044,724,874,1043,1041,1042,940,1258,1563,746,745,856,634,861,416,864,769,980,369,743