All patients
Age < 65y (younger) Age > 65y Asian type cell type, adenocarcinoma cell cell type, non squamous cell cell type, squamous cell ECOG ⩾ 1 ECOG 0 ECOG 1 EGFR mutant EGFR mutation Ex19del EGFR mutation L858R EGFR negative EGFR positive EGFR wild type Gender, female Gender, male RAS mutant RAS wild type smoker (current or former) smoker (Current) smoker (Former) smoker (never) stage I stage II stage IIIa stage IIIb stage IV (metastatic)
Top evidence (RCT only, high risk of bias excluded)
Best available evidence (possibly low or very low)
All RCTs
All studies (RCT+OBS)
lung cancer : non small cell (NSCLC), ... vs. all, meta-analysis of study results Outcome TE 95% CI n k I2 ROB Pub. bias deaths (OS)detailed results A7471028, 2012 (REV) 1.25 [0.88; 1.78]
ARCHER 1009 (all population), 2014 (REV) 0.93 [0.78; 1.09]
ARCHER 1009 (KRAS wild type), 2014 (REV) 0.91 [0.74; 1.13]
CTONG 0901, 2017 0.84 [0.63; 1.12]
DELTA, 2014 0.91 [0.68; 1.22]
ENSURE, 2015 0.91 [0.62; 1.33]
LUX-LUNG 8, 2015 (REV) 1.23 [1.05; 1.45]
NCIC CTG BR.21, 2005 0.70 [0.58; 0.85]
RADIANT, 2015 1.13 [0.88; 1.45]
TOPICAL, 2012 0.92 [0.79; 1.08]
WJOG 5108L, 2016 (REV) 0.96 [0.77; 1.20]
ZEST, 2011 (REV) 1.03 [0.91; 1.17]
0.96 [0.88 ; 1.06 ] A7471028, 2012 (REV), ARCHER 1009 (all population), 2014 (REV), ARCHER 1009 (KRAS wild type), 2014 (REV), CTONG 0901, 2017, DELTA, 2014, ENSURE, 2015, LUX-LUNG 8, 2015 (REV), NCIC CTG BR.21, 2005, RADIANT, 2015, TOPICAL, 2012, WJOG 5108L, 2016 (REV), ZEST, 2011 (REV) 12 59% 7,327 moderate low progression or deaths (PFS)detailed results A7471028, 2012 (REV) 1.52 [1.09; 2.11]
ARCHER 1009 (all population), 2014 (REV) 1.06 [0.91; 1.25]
ARCHER 1009 (KRAS wild type), 2014 (REV) 0.98 [0.80; 1.20]
CTONG 0901, 2017 0.81 [0.62; 1.05]
DELTA, 2014 1.22 [0.97; 1.54]
ENSURE, 2015 0.34 [0.22; 0.52]
LUX-LUNG 8, 2015 (REV) 1.23 [1.05; 1.46]
NCIC CTG BR.21, 2005 0.61 [0.51; 0.73]
TOPICAL, 2012 0.80 [0.68; 0.94]
TORCH, 2008 1.53 [1.32; 1.78]
WJOG 5108L, 2016 (REV) 0.89 [0.74; 1.06]
ZEST, 2011 (REV) 1.02 [0.91; 1.15]
0.95 [0.80 ; 1.13 ] A7471028, 2012 (REV), ARCHER 1009 (all population), 2014 (REV), ARCHER 1009 (KRAS wild type), 2014 (REV), CTONG 0901, 2017, DELTA, 2014, ENSURE, 2015, LUX-LUNG 8, 2015 (REV), NCIC CTG BR.21, 2005, TOPICAL, 2012, TORCH, 2008, WJOG 5108L, 2016 (REV), ZEST, 2011 (REV) 12 90% 7,114 moderate low DCRdetailed results LUX-LUNG 8, 2015 (REV) 0.64 [0.48; 0.85]
WJOG 5108L, 2016 (REV) 0.98 [0.70; 1.38]
0.78 [0.52 ; 1.19 ] LUX-LUNG 8, 2015 (REV), WJOG 5108L, 2016 (REV) 2 72% 1,354 moderate not evaluable events or deaths (EFS)detailed results RADIANT, 2015 0.90 [0.74; 1.10]
0.90 [0.74 ; 1.10 ] RADIANT, 2015 1 0% 973 NA not evaluable objective responses (ORR)detailed results A7471028, 2012 (REV) 0.27 [0.10; 0.78]
ARCHER 1009 (all population), 2014 (REV) 0.69 [0.44; 1.09]
ARCHER 1009 (KRAS wild type), 2014 (REV) 0.84 [0.49; 1.42]
CTONG 0901, 2017 1.33 [0.81; 2.18]
DELTA, 2014 0.96 [0.53; 1.76]
LUX-LUNG 8, 2015 (REV) 0.49 [0.23; 1.02]
NCIC CTG BR.21, 2005 10.18 [2.43; 42.54]
TOPICAL, 2012 2.00 [0.81; 4.98]
WJOG 5108L, 2016 (REV) 0.93 [0.65; 1.33]
ZEST, 2011 (REV) 1.00 [0.71; 1.40]
0.95 [0.70 ; 1.29 ] A7471028, 2012 (REV), ARCHER 1009 (all population), 2014 (REV), ARCHER 1009 (KRAS wild type), 2014 (REV), CTONG 0901, 2017, DELTA, 2014, LUX-LUNG 8, 2015 (REV), NCIC CTG BR.21, 2005, TOPICAL, 2012, WJOG 5108L, 2016 (REV), ZEST, 2011 (REV) 10 65% 6,049 moderate low AE (any grade)detailed results LUX-LUNG 8, 2015 (REV) 0.20 [0.04; 0.91]
0.20 [0.04 ; 0.91 ] LUX-LUNG 8, 2015 (REV) 1 0% 787 NA not evaluable AE (grade 3-4)detailed results LUX-LUNG 8, 2015 (REV) 1.02 [0.77; 1.36]
1.02 [0.77 ; 1.36 ] LUX-LUNG 8, 2015 (REV) 1 0% 787 NA not evaluable SAE (any grade)detailed results LUX-LUNG 8, 2015 (REV) 1.00 [0.75; 1.32]
1.00 [0.75 ; 1.32 ] LUX-LUNG 8, 2015 (REV) 1 0% 787 NA not evaluable STRAE (any grade)detailed results LUX-LUNG 8, 2015 (REV) 0.43 [0.26; 0.73]
0.43 [0.26 ; 0.73 ] LUX-LUNG 8, 2015 (REV) 1 0% 787 NA not evaluable TRAE (any grade)detailed results ARCHER 1009 (all population), 2014 (REV) 0.56 [0.34; 0.94]
LUX-LUNG 8, 2015 (REV) 0.31 [0.19; 0.49]
0.41 [0.23 ; 0.75 ] ARCHER 1009 (all population), 2014 (REV), LUX-LUNG 8, 2015 (REV) 2 66% 1,659 moderate not evaluable TRAE (grade 3-4)detailed results ARCHER 1009 (all population), 2014 (REV) 0.60 [0.44; 0.81]
LUX-LUNG 8, 2015 (REV) 0.56 [0.40; 0.80]
0.58 [0.46 ; 0.73 ] ARCHER 1009 (all population), 2014 (REV), LUX-LUNG 8, 2015 (REV) 2 0% 1,667 low not evaluable TRAE leading to death (grade 5)detailed results A7471028, 2012 (REV) 0.99 [0.14; 7.17]
ARCHER 1009 (all population), 2014 (REV) 0.25 [0.03; 2.23]
LUX-LUNG 8, 2015 (REV) 0.82 [0.25; 2.73]
0.69 [0.27 ; 1.75 ] A7471028, 2012 (REV), ARCHER 1009 (all population), 2014 (REV), LUX-LUNG 8, 2015 (REV) 3 0% 1,846 moderate not evaluable TRAE leading to discontinuation (any grade)detailed results A7471028, 2012 (REV) 0.27 [0.05; 1.32]
LUX-LUNG 8, 2015 (REV) 0.81 [0.56; 1.16]
0.62 [0.24 ; 1.57 ] A7471028, 2012 (REV), LUX-LUNG 8, 2015 (REV) 2 43% 974 moderate not evaluable 0.0 2.0 1.0 relative treatment effect www.metaEvidence.org 2024-09-30 10:55 +02:00
TE: relative treatment effect (measured by a risk ratio, an odds ratio or an hazard ratio depending on what is reported in the papers);
k: number of studies; n: total number of patients;
ROB: risk of bias (ROB 2.0); Pub. bias: publication bias; OBS: observational studies; RCT: randomized clinical trials
pathologies: 161,226,41,225,182,198,179,200,195,254,242,243,199,190,229,266,191,196,36,228,174,171,173,307,165,163,176,308,164,166,220,197,255,37,245,204,244,241,227,217,177,279,167,1,170,261,280,168,169,335,334
- treatments: 430
