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mNSCLC - L2 - all population, ... , meta-analysis of study results

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

deaths (OS) 1.00 [0.70, 1.43]< 10%1 study (1/-)50.0 %NAnot evaluable crucial-
progression or deaths (PFS) 0.60 [0.43, 0.84]< 10%1 study (1/-)99.8 %NAnot evaluable important-
DCR 3.51 [1.90, 6.50]> 10%1 study (1/-)100.0 %NAnot evaluable non important-
objective responses (ORR) 3.41 [1.55, 7.48]> 10%1 study (1/-)99.9 %NAnot evaluable non important-

safety endpoints 00

TRAE (any grade) 3.34 [1.55, 7.22]< 10%1 study (1/-)0.1 %NAnot evaluable non important-
TRAE (grade 3-4) 2.38 [1.23, 4.59]< 10%1 study (1/-)0.5 %NAnot evaluable non important-
TRAE leading to death (grade 5) 0.22 [0.01, 6.78]< 10%1 study (1/-)80.1 %NAnot evaluable non important-
TRAE leading to discontinuation (any grade) 3.27 [1.08, 9.86]< 10%1 study (1/-)1.8 %NAnot evaluable non important-
TRAE leading to discontinuation (grade 3-4) 3.17 [0.69, 14.51]< 10%1 study (1/-)6.9 %NAnot evaluable non important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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