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non squamous cell - mNSCLC - L2, ... , meta-analysis of study results

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

deaths (OS) 0.81 [0.69, 0.95]< 10%1 study (1/-)99.5 %NAnot evaluable crucial-
progression or deaths (PFS) 0.81 [0.69, 0.96]< 10%1 study (1/-)99.4 %NAnot evaluable important-
DCR 1.56 [1.18, 2.07]> 10%1 study (1/-)99.9 %NAnot evaluable non important-
objective responses (ORR) 2.05 [0.98, 4.29]> 10%1 study (1/-)97.2 %NAnot evaluable non important-

safety endpoints 00

AE (any grade) 5.06 [1.10, 23.27]< 10%1 study (1/-)1.9 %NAnot evaluable non important-
AE (grade 3-4) 0.98 [0.74, 1.29]< 10%1 study (1/-)56.6 %NAnot evaluable non important-
SAE (any grade) 1.00 [0.76, 1.33]< 10%1 study (1/-)49.1 %NAnot evaluable non important-
STRAE (any grade) 2.31 [1.36, 3.91]< 10%1 study (1/-)0.1 %NAnot evaluable non important-
TRAE (any grade) 3.25 [2.03, 5.20]< 10%1 study (1/-)0.0 %NAnot evaluable non important-
TRAE (grade 3-4) 1.77 [1.25, 2.51]< 10%1 study (1/-)0.1 %NAnot evaluable non important-
TRAE leading to death (grade 5) 1.21 [0.37, 4.01]< 10%1 study (1/-)37.6 %NAnot evaluable non important-
TRAE leading to discontinuation (any grade) 1.24 [0.86, 1.77]< 10%1 study (1/-)12.5 %NAnot evaluable non important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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