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metastatic/advanced NSCLC (mNSCLC) - 2nd line (L2), gene alteration target therapy , meta-analysis of study results

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

deaths (OS) 0.88 [0.67, 1.16]< 10%3 studies (3/-)82.1 %some concernnot evaluable moderatecrucial-
progression or deaths (PFS) 0.30 [0.19, 0.46]< 138%3 studies (3/-)100.0 %some concernnot evaluable moderateimportant-
DCR 3.85 [2.18, 6.82]> 10%1 study (1/-)100.0 %NAnot evaluable non important-
objective responses (ORR) 4.20 [0.99, 17.75]> 186%3 studies (3/-)97.4 %some concernnot evaluable moderatenon important-

safety endpoints 00

AE (any grade) 0.46 [0.07, 3.03]< 10%2 studies (2/-)78.7 %some concernnot evaluable moderatenon important-
AE (grade 3-4) 1.65 [0.05, 60.04]< 190%2 studies (2/-)39.4 %some concernnot evaluable moderatenon important-
AE leading to death (grade 5) 1.54 [0.22, 10.60]< 10%2 studies (2/-)33.1 %some concernnot evaluable moderatenon important-
TRAE (any grade) 0.92 [0.27, 3.19]< 153%2 studies (2/-)55.2 %some concernnot evaluable moderatenon important-
TRAE (grade 3-4) 0.69 [0.01, 36.44]< 185%2 studies (2/-)57.1 %some concernnot evaluable moderatenon important-
TRAE leading to death (grade 5) 0.99 [0.02, 50.39]< 10%1 study (1/-)50.3 %NAnot evaluable non important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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