pdf   xlsx method abbreviations

lung cancer : non small cell (NSCLC), ... , meta-analysis of study results

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

deaths (OS) 0.87 [0.74, 1.03]< 114%3 studies (3/-)94.9 %some concernnot evaluable moderatecrucial-
progression or deaths (PFS) 0.48 [0.25, 0.92]< 194%3 studies (3/-)98.7 %some concernnot evaluable moderateimportant-
DCR 2.34 [0.97, 5.62]> 185%2 studies (2/-)97.1 %some concernnot evaluable moderatenon important-
objective responses (ORR) 4.11 [2.26, 7.45]> 170%3 studies (3/-)100.0 %some concernnot evaluable moderatenon important-

safety endpoints 00

AE (any grade) 5.06 [1.10, 23.27]< 10%1 study (1/-)1.9 %NAnot evaluable non important-
AE (grade 3-4) 0.98 [0.74, 1.29]< 10%1 study (1/-)56.6 %NAnot evaluable non important-
SAE (any grade) 1.00 [0.76, 1.33]< 10%1 study (1/-)49.1 %NAnot evaluable non important-
STRAE (any grade) 2.31 [1.36, 3.91]< 10%1 study (1/-)0.1 %NAnot evaluable non important-
TRAE (any grade) 2.30 [0.66, 8.05]< 140%2 studies (2/-)9.7 %some concernnot evaluable moderatenon important-
TRAE (grade 3-4) 0.88 [0.36, 2.15]< 193%3 studies (3/-)61.3 %some concernnot evaluable moderatenon important-
TRAE leading to death (grade 5) 1.23 [0.44, 3.44]< 10%3 studies (3/-)34.7 %some concernnot evaluable moderatenon important-
TRAE leading to discontinuation (any grade) 0.45 [0.09, 2.12]< 196%3 studies (3/-)84.4 %some concernnot evaluable moderatenon important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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