pdf   xlsx method abbreviations

lung cancer : non small cell (NSCLC), ... , meta-analysis of study results

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

deaths (OS) 0.94 [0.80, 1.10]< 150%4 studies (4/-)79.1 %lownot evaluable highcrucial-
deaths (OS) (extension) 0.75 [0.59, 0.95]< 10%1 study (1/-)99.2 %NAnot evaluable important-
progression or deaths (PFS) 0.71 [0.56, 0.90]< 179%4 studies (4/-)99.8 %lownot evaluable highimportant-
objective responses (ORR) 1.79 [0.69, 4.64]> 187%4 studies (4/-)88.5 %lownot evaluable highnon important-

safety endpoints 00

AE (any grade) 4.11 [0.46, 37.05]< 10%1 study (1/-)10.5 %NAnot evaluable non important-
AE (grade 3-4) 2.41 [1.64, 3.53]< 10%1 study (1/-)0.0 %NAnot evaluable non important-
AE leading to treatment discontinuation (any grade) 3.87 [0.56, 26.81]< 185%2 studies (2/-)8.6 %lownot evaluable highnon important-
SAE (any grade) 1.13 [0.82, 1.56]< 10%1 study (1/-)23.3 %NAnot evaluable non important-
TRAE (any grade) 1.77 [1.07, 2.93]< 10%1 study (1/-)1.3 %NAnot evaluable non important-
TRAE (grade 3-4) 1.68 [1.23, 2.28]< 10%1 study (1/-)0.0 %NAnot evaluable non important-
TRAE leading to death (grade 5) 2.06 [0.55, 7.72]< 10%3 studies (3/-)14.2 %lownot evaluable highnon important-
TRAE leading to discontinuation (any grade) 1.76 [0.89, 3.50]< 17%2 studies (2/-)5.4 %lownot evaluable highnon important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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