Outcome |
Relative effect 95%CI |
LoD |
Trt. better when |
|
I2 |
k (RCT/OBS)
|
Bayesian probability
|
Overall ROB
|
Publication bias |
Degree of certainty |
Endpoint importance |
Published MA |
efficacy endpoints 00 |
deaths (OS) | 1.00 [0.86, 1.16] | | < 1 | | 16% | 2 studies (2/-) | 49.2 % | some concern | not evaluable | moderate | crucial | - |
progression or deaths (PFS) | 1.58 [1.37, 1.82] | | < 1 | | 5% | 2 studies (2/-) | 0.0 % | some concern | not evaluable | moderate | important | - |
DCR | 0.37 [0.23, 0.60] | | > 1 | | 0% | 1 study (1/-) | 0.0 % | NA | not evaluable | | non important | - |
objective responses (ORR) | 0.81 [0.51, 1.28] | | > 1 | | 0% | 2 studies (2/-) | 18.3 % | some concern | not evaluable | moderate | non important | - |
safety endpoints 00 |
TRAE (any grade) | 0.26 [0.17, 0.42] | | < 1 | | 57% | 2 studies (2/-) | 100.0 % | some concern | not evaluable | moderate | non important | - |
TRAE (grade 3-4) | 0.28 [0.20, 0.39] | | < 1 | | 0% | 2 studies (2/-) | 100.0 % | some concern | not evaluable | moderate | non important | - |
TRAE leading to death (grade 5) | 1.64 [0.25, 10.83] | | < 1 | | 0% | 2 studies (2/-) | 30.5 % | some concern | not evaluable | moderate | non important | - |
TRAE leading to discontinuation (any grade) | 0.62 [0.32, 1.19] | | < 1 | | 0% | 2 studies (2/-) | 92.6 % | some concern | not evaluable | moderate | non important | - |
TRAE (grade 3-4) endpoints 00 |
Alopecia TRAE (grade 3-4) | 0.30 [0.03, 3.29] | | < 1 | | 0% | 2 studies (2/-) | 83.5 % | some concern | not evaluable | moderate | non important | - |
Anaemia TRAE (grade 3-4) | 0.21 [0.02, 2.39] | | < 1 | | 65% | 2 studies (2/-) | 89.3 % | some concern | not evaluable | moderate | non important | - |
Asthenia TRAE (grade 3-4) | 0.19 [0.02, 1.63] | | < 1 | | 0% | 1 study (1/-) | 93.4 % | NA | not evaluable | | non important | - |
Colitis TRAE (grade 3-4) | 0.16 [0.01, 3.11] | | < 1 | | 0% | 1 study (1/-) | 88.6 % | NA | not evaluable | | non important | - |
Decreased appetite TRAE (grade 3-4) | 0.64 [0.02, 19.22] | | < 1 | | 60% | 2 studies (2/-) | 59.9 % | some concern | not evaluable | moderate | non important | - |
Diabetes TRAE (grade 3-4) | 0.94 [0.02, 47.47] | | < 1 | | 0% | 1 study (1/-) | 51.2 % | NA | not evaluable | | non important | - |
Diarrhoea TRAE (grade 3-4) | 0.30 [0.06, 1.66] | | < 1 | | 1% | 2 studies (2/-) | 91.4 % | some concern | not evaluable | moderate | non important | - |
Fatigue TRAE (grade 3-4) | 0.49 [0.21, 1.17] | | < 1 | | 0% | 2 studies (2/-) | 94.5 % | some concern | not evaluable | moderate | non important | - |
Febrile neutropenia TRAE (grade 3-4) | 0.08 [0.00, 1.40] | | < 1 | | 0% | 1 study (1/-) | 95.7 % | NA | not evaluable | | non important | - |
Hepatitis TRAE (grade 3-4) | 7.60 [0.40, 144.43] | | < 1 | | 0% | 1 study (1/-) | 9.1 % | NA | not evaluable | | non important | - |
Hyperthyroidism TRAE (grade 3-4) | 0.94 [0.02, 47.47] | | < 1 | | 0% | 1 study (1/-) | 51.2 % | NA | not evaluable | | non important | - |
Hypophysitis TRAE (grade 3-4) | 3.77 [0.17, 84.06] | | < 1 | | 0% | 1 study (1/-) | 20.4 % | NA | not evaluable | | non important | - |
Hypothyroidism TRAE (grade 3-4) | 0.94 [0.02, 47.47] | | < 1 | | 0% | 1 study (1/-) | 51.2 % | NA | not evaluable | | non important | - |
Increase AST TRAE (grade 3-4) | 1.29 [0.28, 5.84] | | < 1 | | 0% | 1 study (1/-) | 37.1 % | NA | not evaluable | | non important | - |
Increased ALT TRAE (grade 3-4) | 0.72 [0.16, 3.25] | | < 1 | | 0% | 1 study (1/-) | 66.7 % | NA | not evaluable | | non important | - |
Increased lipase level TRAE (grade 3-4) | 0.48 [0.04, 5.32] | | < 1 | | 0% | 1 study (1/-) | 72.4 % | NA | not evaluable | | non important | - |
Infusion-related reactions TRAE (grade 3-4) | 0.95 [0.09, 10.52] | | < 1 | | 0% | 2 studies (2/-) | 51.6 % | some concern | not evaluable | moderate | non important | - |
Nausea TRAE (grade 3-4) | 0.36 [0.05, 2.43] | | < 1 | | 0% | 2 studies (2/-) | 85.1 % | some concern | not evaluable | moderate | non important | - |
Neutropenia TRAE (grade 3-4) | 0.02 [0.00, 0.12] | | < 1 | | 0% | 2 studies (2/-) | 100.0 % | some concern | not evaluable | moderate | non important | - |
Pancreatitis TRAE (grade 3-4) | 0.47 [0.02, 14.02] | | < 1 | | 0% | 1 study (1/-) | 66.7 % | NA | not evaluable | | non important | - |
Peripheral neuropathy TRAE (grade 3-4) | 0.08 [0.00, 1.38] | | < 1 | | 0% | 1 study (1/-) | 95.8 % | NA | not evaluable | | non important | - |
Pneumonitis TRAE (grade 3-4) | 3.77 [0.17, 84.06] | | < 1 | | 0% | 1 study (1/-) | 20.4 % | NA | not evaluable | | non important | - |
Severe skin reaction TRAE (grade 3-4) | 1.88 [0.06, 56.28] | | < 1 | | 0% | 1 study (1/-) | 36.0 % | NA | not evaluable | | non important | - |
Vomiting TRAE (grade 3-4) | 0.24 [0.01, 5.32] | | < 1 | | 0% | 1 study (1/-) | 81.4 % | NA | not evaluable | | non important | - |
Weight decreased TRAE (grade 3-4) | 0.07 [0.00, 1.17] | | < 1 | | 0% | 1 study (1/-) | 96.6 % | NA | not evaluable | | non important | - |