pdf   xlsx method abbreviations

lung cancer : non small cell (NSCLC), ... versus chemotherapy, meta-analysis of study results

Outcome Relative effect 95%CI LoD Trt. better when I2 k (RCT/OBS) Bayesian probability Overall ROB Publication bias Degree of certainty Endpoint importance Published MA

efficacy endpoints 00

deaths (OS) 0.75 [0.54, 1.02]< 149%2 studies (2/-)96.5 %some concernnot evaluable moderatecrucial-
progression or deaths (PFS) 0.38 [0.25, 0.57]< 181%2 studies (2/-)100.0 %lownot evaluable highimportant-
DCR 3.52 [2.20, 5.64]> 10%2 studies (2/-)100.0 %some concernnot evaluable moderatenon important-
objective responses (ORR) 2.61 [0.63, 10.75]> 195%2 studies (2/-)90.7 %lownot evaluable highnon important-

safety endpoints 00

AE (any grade) 0.79 [0.29, 2.16]< 10%2 studies (2/-)67.8 %lownot evaluable highnon important-
AE (grade 3-4) 0.46 [0.22, 0.98]< 186%2 studies (2/-)97.8 %lownot evaluable highnon important-
AE leading to death (grade 5) 0.73 [0.29, 1.85]< 10%2 studies (2/-)74.8 %lownot evaluable highnon important-
AE leading to treatment discontinuation (any grade) 0.71 [0.45, 1.13]< 10%1 study (1/-)92.5 %NAnot evaluable non important-
SAE (any grade) 0.81 [0.55, 1.20]< 10%1 study (1/-)85.3 %NAnot evaluable non important-
TRAE (any grade) 0.46 [0.34, 0.63]< 10%2 studies (2/-)100.0 %lownot evaluable highnon important-
TRAE (grade 3-4) 0.12 [0.06, 0.22]< 10%1 study (1/-)100.0 %NAnot evaluable non important-

LoD: level of statistical demonstration: Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant; safety concerns;
Bayesian probability: Bayesian posterior probability of treatment effect (computed with a noninformative prior); ROB: risk of bias; k: number of studies; published MA: number of published meta-analysis on the same topic; degree of certainty adapted from GRADE. Trt. better when: indicates when the relative treatment effect shows that the studied treatment is better than control.



 

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